Division of RI application, Korea Institute of Radiological and Medical Sciences, 75 Nowon-Gil, Gongneung-Dong, Nowon-Gu, Seoul, 01812, Korea.
Research support team, ANDIVA Inc., Chuncheon, Korea.
BMC Cancer. 2019 Feb 13;19(1):149. doi: 10.1186/s12885-019-5323-z.
Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in the treatment of chemotherapy-induced alopecia, there is no effective treatment for preventing chemotherapy-induced alopecia.
In the present study, we investigated the potential role of a multi-target iron chelator, M30 in protecting against cyclophosphamide-induced alopecia in C57BL/6 mice implanted with an osmotic pump. M30 enhanced hair growth and prevented cyclophosphamide-induced abnormal hair in the mice. Furthermore, we examined the gene expression profiles derived from skin biopsy specimens of normal mice, cyclophosphamide-treated mice, and cyclophosphamide treated mice with M30 supplement.
The top genes namely Tnfrsf19, Ercc2, Lama5, Ctsl, and Per1 were identified by microarray analysis. These genes were found to be involved in the biological processes of hair cycle, hair cycle phase, hair cycle process, hair follicle development, hair follicle maturation, hair follicle morphogenesis, regulation of hair cycle.
Our study demonstrates that M30 treatment is a promising therapy for cyclophosphamide-induced alopecia and suggests that the top five genes have unique preventive effects in cyclophosphamide-induced transformation.
化疗引起的脱发已被充分证明是癌症治疗患者苦恼的原因。几乎所有传统的化疗药物都会引起严重的脱发。尽管在治疗化疗引起的脱发方面取得了进展，但仍没有有效的预防化疗引起的脱发的治疗方法。
在本研究中，我们研究了多靶点铁螯合剂 M30 对植入渗透泵的 C57BL/6 小鼠环磷酰胺诱导性脱发的潜在作用。M30 促进了毛发的生长并预防了环磷酰胺引起的小鼠异常毛发。此外，我们检查了正常小鼠、环磷酰胺处理小鼠和 M30 补充的环磷酰胺处理小鼠的皮肤活检标本的基因表达谱。
通过微阵列分析鉴定了 top 基因，即 Tnfrsf19、Ercc2、Lama5、Ctsl 和 Per1。这些基因被发现参与了毛发生长、毛发生长周期、毛发生长过程、毛囊发育、毛囊成熟、毛囊形态发生、毛发生长周期调节等生物学过程。
我们的研究表明，M30 治疗是一种有前途的治疗环磷酰胺诱导性脱发的方法，并表明 top 五个基因在环磷酰胺诱导的转化中具有独特的预防作用。
