Hajloo Nader, Pouresmali Asghar, Alizadeh Goradel Jaber, Mowlaie Mehri
Department of Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Young Researchers and Elite Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
Iran J Psychiatry. 2019 Oct;14(4):291-296.
Tobacco smoking is an addictive behavior with many psychological side effects, and many smokers are unable to quit it. Despite various treatments for smoking cessation, there is an urgent need to develop and utilize a noninvasive technique with high efficacy. This study aimed to determine the effects of transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) on reduction of craving in daily and social smokers. This pretest-posttest quasi-experimental study, in which the participants were randomly assigned into sham and active groups, was performed on 40 daily and social smokers. Stimulation was delivered over the left DLPFC at a 2 m/A during 10 twenty-minute sessions for 5 weeks. The participants filled out the Desire for Drug questionnaire (DDQ) before and after intervention. Analysis of covariance was used for data analysis. A significant decrease was found in the number of cigarette smoking in both daily and social smokers compared to the sham group. Moreover, the results indicated that anodal tDCS on F3 and Cathodal tDCS on F4 has significant effects on nicotine craving (P < 0/000). The results of the present study showed that the current tDCS of DLPFC decreases the craving of smoking. This noninvasive brain stimulation technique targeted at DLPFC area may be a promising method for reducing and treating smoking craving.
吸烟是一种具有多种心理副作用的成瘾行为，许多吸烟者无法戒烟。尽管有各种戒烟治疗方法，但迫切需要开发和利用一种高效的非侵入性技术。本研究旨在确定经颅直流电刺激（tDCS）背外侧前额叶皮层（DLPFC）对减少日常吸烟者和社交吸烟者烟瘾的效果。 这项前后测准实验研究对40名日常吸烟者和社交吸烟者进行，参与者被随机分为假刺激组和真刺激组。在5周内，以2毫安的电流强度对左侧DLPFC进行10次每次20分钟的刺激。参与者在干预前后填写药物渴望问卷（DDQ）。采用协方差分析进行数据分析。 与假刺激组相比，日常吸烟者和社交吸烟者的吸烟量均显著减少。此外，结果表明，F3处的阳极tDCS和F4处的阴极tDCS对尼古丁渴望有显著影响（P<0.000）。 本研究结果表明，当前对DLPFC的tDCS可降低吸烟渴望。这种针对DLPFC区域的非侵入性脑刺激技术可能是减少和治疗吸烟渴望的一种有前景的方法。
