Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
BMJ Mil Health. 2020 Aug;166(4):221-226. doi: 10.1136/jramc-2018-001119. Epub 2019 Feb 13.
Rotational shift work has a considerable effect on immune function and cause inflammation. In addition, it may lead to unhealthy dietary intake. No earlier study has examined the association between dietary patterns and inflammation in rotational shift workers. Therefore, this study was conducted to investigate the association between dietary patterns and circulating proinflammatory cytokines among shift workers.
This cross-sectional study was conducted among 257 male shift workers. Dietary intake of participants was examined using the semiquantitative Food Frequency Questionnaire. Serum concentrations of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) were measured using suitable commercial kits.
Three main dietary patterns included green vegetables, yellow vegetables and cruciferous vegetables (VEG), liquid oils and mayonnaise, fast food and eggs (LFE), as well as tea and coffee, refined grains and spice (TRS). Subjects with the highest adherence to VEG dietary pattern had a significantly lower concentration of IL-6 (p<0.01) and TNF-α (p<0.001) as compared with those with the lowest adherence. On the other hand, a significant negative association was found between LFE dietary pattern and serum concentrations of IL-6 (p=0.01) and TNF-α (p=0.02). However, no significant association was found between adherence to VEG (p=0.34) or LFE (p=0.99) dietary patterns and levels of hs-CRP and between adherence to TRS dietary pattern and any of the inflammatory cytokines.
Adherence to VEG and LFE dietary patterns was inversely and directly associated to serum IL-6 and TNF-α concentrations in shift workers, respectively. However, no significant association was found between adherence to these two dietary patterns and serum hs-CRP concentrations and between TRS dietary pattern and any of the inflammatory cytokines.
轮班工作会对免疫功能产生重大影响，并导致炎症。此外，它可能导致不健康的饮食摄入。之前没有研究调查过轮班工作者的饮食模式与炎症之间的关系。因此，本研究旨在调查轮班工作者饮食模式与循环促炎细胞因子之间的关系。
本横断面研究在 257 名男性轮班工人中进行。使用半定量食物频率问卷评估参与者的饮食摄入。使用合适的商业试剂盒测量血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和高敏 C 反应蛋白（hs-CRP）的浓度。
三种主要的饮食模式包括绿叶蔬菜、黄色蔬菜和十字花科蔬菜（VEG）、液体油和蛋黄酱、快餐和鸡蛋（LFE）以及茶和咖啡、精制谷物和香料（TRS）。与最低依从性相比，最高依从性 VEG 饮食模式的受试者 IL-6（p<0.01）和 TNF-α（p<0.001）的浓度明显较低。另一方面，LFE 饮食模式与血清 IL-6（p=0.01）和 TNF-α（p=0.02）浓度呈显著负相关。然而，VEG（p=0.34）或 LFE（p=0.99）饮食模式的依从性与 hs-CRP 水平之间以及 TRS 饮食模式的依从性与任何一种炎症细胞因子之间均无显著相关性。
轮班工人血清 IL-6 和 TNF-α 浓度与 VEG 和 LFE 饮食模式的依从性呈负相关和直接相关。然而，这两种饮食模式的依从性与血清 hs-CRP 浓度之间以及 TRS 饮食模式与任何炎症细胞因子之间均无显著相关性。
