J Acad Nutr Diet. 2014 May;114(5):700-8.e2. doi: 10.1016/j.jand.2013.12.019. Epub 2014 Mar 13.
Higher intakes of cruciferous vegetables or their constituents have been shown to lower inflammation in animal studies. However, evidence for this anti-inflammatory effect of cruciferous vegetable consumption in humans is scarce.
OBJECTIVE/DESIGN: In this cross-sectional analysis, we evaluated associations of vegetable intake with a panel of inflammatory and oxidative stress markers among 1,005 middle-aged Chinese women. Dietary intake of foods was assessed by a food frequency questionnaire.
Multivariable-adjusted circulating concentrations of tumor necrosis factor-α (TNF-α), interlukin-1β (IL-1β), and IL-6 were lower among women with higher intakes of cruciferous vegetables. The differences in concentrations of inflammatory biomarkers between extreme quintiles of cruciferous vegetable intake were 12.66% for TNF-α (Ptrend=0.01), 18.18% for IL-1β (Ptrend=0.02), and 24.68% for IL-6 (Ptrend=0.02). A similar, but less apparent, inverse association was found for intakes of all vegetables combined but not for noncruciferous vegetables. Levels of the urinary oxidative stress markers F2-isoprostanes and their major metabolite, 2,3-dinor-5,6-dihydro-15-F2t-IsoP, were not associated with intakes of cruciferous vegetables or all vegetables combined.
This study suggests that the previously observed health benefits of cruciferous vegetable consumption may be partly associated with the anti-inflammatory effects of these vegetables.
动物研究表明，摄入更多十字花科蔬菜或其成分可降低炎症。然而，十字花科蔬菜消费对人类抗炎作用的证据很少。
目的/设计：在这项横断面分析中，我们评估了 1005 名中国中年女性中蔬菜摄入量与一系列炎症和氧化应激标志物之间的关联。通过食物频率问卷评估食物的饮食摄入量。
多变量调整后的循环肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）浓度在摄入更多十字花科蔬菜的女性中较低。在十字花科蔬菜摄入量的极端五分位数之间，炎症生物标志物的浓度差异为 12.66%（TNF-α，Ptrend=0.01）、18.18%（IL-1β，Ptrend=0.02）和 24.68%（IL-6，Ptrend=0.02）。类似的，但不太明显的反比关系在所有蔬菜的摄入量中发现，但在非十字花科蔬菜中没有发现。尿液氧化应激标志物 F2-异前列腺素及其主要代谢物 2,3-二去-5,6-二氢-15-F2t-IsoP 的水平与十字花科蔬菜或所有蔬菜的摄入量均无关联。
这项研究表明，先前观察到的十字花科蔬菜消费的健康益处可能部分与这些蔬菜的抗炎作用有关。
