Nettleton Jennifer A, Steffen Lyn M, Mayer-Davis Elizabeth J, Jenny Nancy S, Jiang Rui, Herrington David M, Jacobs David R
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Am J Clin Nutr. 2006 Jun;83(6):1369-79. doi: 10.1093/ajcn/83.6.1369.
Dietary patterns may influence cardiovascular disease risk through effects on inflammation and endothelial activation.
We examined relations between dietary patterns and markers of inflammation and endothelial activation.
At baseline, diet (food-frequency questionnaire) and concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), homocysteine, soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E selectin were assessed in 5089 nondiabetic participants in the Multi-Ethnic Study of Atherosclerosis.
Four dietary patterns were derived by using factor analysis. The fats and processed meats pattern (fats, oils, processed meats, fried potatoes, salty snacks, and desserts) was positively associated with CRP (P for trend < 0.001), IL-6 (P for trend < 0.001), and homocysteine (P for trend = 0.002). The beans, tomatoes, and refined grains pattern (beans, tomatoes, refined grains, and high-fat dairy products) was positively related to sICAM-1 (P for trend = 0.007). In contrast, the whole grains and fruit pattern (whole grains, fruit, nuts, and green leafy vegetables) was inversely associated with CRP, IL-6, homocysteine (P for trend < or = 0.001), and sICAM-1 (P for trend = 0.034), and the vegetables and fish pattern (fish and dark-yellow, cruciferous, and other vegetables) was inversely related to IL-6 (P for trend = 0.009). CRP, IL-6, and homocysteine relations across the fats and processed meats and whole grains and fruit patterns were independent of demographics and lifestyle factors and were not modified by race-ethnicity. CRP and homocysteine relations were independent of waist circumference.
These results corroborate previous findings that empirically derived dietary patterns are associated with inflammation and show that these relations in an ethnically diverse population with unique dietary habits are similar to findings in more homogeneous populations.
饮食模式可能通过对炎症和内皮激活的影响来影响心血管疾病风险。
我们研究了饮食模式与炎症和内皮激活标志物之间的关系。
在基线时，对动脉粥样硬化多族裔研究中的5089名非糖尿病参与者进行了饮食（食物频率问卷）以及C反应蛋白（CRP）、白细胞介素6（IL-6）、同型半胱氨酸、可溶性细胞间黏附分子-1（sICAM-1）和可溶性E选择素浓度的评估。
通过因子分析得出了四种饮食模式。脂肪和加工肉类模式（脂肪、油类、加工肉类、炸土豆、咸味小吃和甜点）与CRP（趋势P<0.001）、IL-6（趋势P<0.001）和同型半胱氨酸（趋势P=0.002）呈正相关。豆类、番茄和精制谷物模式（豆类、番茄、精制谷物和高脂肪乳制品）与sICAM-1呈正相关（趋势P=0.007）。相比之下，全谷物和水果模式（全谷物、水果、坚果和绿叶蔬菜）与CRP、IL-6、同型半胱氨酸（趋势P≤0.001）和sICAM-1（趋势P=0.034）呈负相关，而蔬菜和鱼类模式（鱼类以及深黄色、十字花科和其他蔬菜）与IL-6呈负相关（趋势P=0.009）。脂肪和加工肉类模式与全谷物和水果模式之间的CRP、IL-6和同型半胱氨酸关系独立于人口统计学和生活方式因素，且不受种族影响。CRP和同型半胱氨酸关系独立于腰围。
这些结果证实了先前的研究发现，即根据经验得出的饮食模式与炎症相关，并表明在具有独特饮食习惯的多族裔人群中，这些关系与在更为同质的人群中的发现相似。
