Bshiebish Hasanain Ali Hameed, Al-Musawi Ali Hussein, Khudeir Safaa Ali
Al-Najaf centre for heart disease, Najaf, Iraq.
College of Medicine, University of Kufa, Najaf, Iraq.
J Saudi Heart Assoc. 2019 Apr;31(2):100-105. doi: 10.1016/j.jsha.2018.12.002. Epub 2019 Jan 21.
To detect systolic dysfunction in heart failure with preserved ejection fraction (HFpEF) patients by using global longitudinal strain (GLS).
This study included 46 heart failure patients: 24 with heart failure with reduced ejection fraction (HFrEF) and 22 with heart failure with preserved ejection fraction (HFpEF), and 20 patients with similar risk factor but no symptoms or signs of heart failure, matched for age and sex, as controls. All patients were screened by echocardiography. The ejection fraction of left ventricle was measured using Simpson's method and the GLS of the left ventricle was measured by using two-dimensional speckle tracking.
Left ventricular ejection fraction (LVEF) was 61.90 ± 2.94% in the controls, 60.45 ± 7.4% in the HFpEF group ( = 0.421), and 32.75 ± 8.45% in the HFrEF group ( = 0.001). The value of left ventricle (LV) GLS (controls = -19.74 ± 1.12%, HFpEF = -15.03 ± 2.03%, HFrEF = -10.72 ± 1.99%, = 0.0001) was significantly impaired in the HFpEF group despite normal LVEF.
There is significant left ventricular systolic impairment detected by GLS despite preserved LVEF.
通过使用整体纵向应变（GLS）检测射血分数保留的心力衰竭（HFpEF）患者的收缩功能障碍。
本研究纳入46例心力衰竭患者：24例射血分数降低的心力衰竭（HFrEF）患者和22例射血分数保留的心力衰竭（HFpEF）患者，以及20例年龄和性别相匹配、具有相似危险因素但无心力衰竭症状或体征的患者作为对照。所有患者均接受超声心动图检查。使用辛普森法测量左心室射血分数，并使用二维斑点追踪法测量左心室的GLS。
对照组左心室射血分数（LVEF）为61.90±2.94%，HFpEF组为60.45±7.4%（P = 0.421），HFrEF组为32.75±8.45%（P = 0.001）。尽管LVEF正常，但HFpEF组左心室（LV）GLS值（对照组=-19.74±1.12%，HFpEF=-15.03±2.03%，HFrEF=-10.72±1.99%，P = 0.0001）显著受损。
尽管LVEF保留，但通过GLS检测到左心室存在明显的收缩功能损害。
