长链非编码RNA NR_046683的上调作为多发性骨髓瘤的预后生物标志物和潜在药物靶点。
Upregulation of lncRNA NR_046683 Serves as a Prognostic Biomarker and Potential Drug Target for Multiple Myeloma.
作者信息
Dong Hang, Jiang Siyi, Fu Yunfeng, Luo Yanwei, Gui Rong, Liu Jing
机构信息
Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha, China.
Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China.
出版信息
Front Pharmacol. 2019 Jan 31;10:45. doi: 10.3389/fphar.2019.00045. eCollection 2019.
To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM). High-throughput lncRNA array was combined with bioinformatics techniques to screen differentially expressed lncRNA in MM. qRT-PCR was adopted to determine the expression of target lncRNAs in MM patients and controls. It was found for the first time that lncRNA NR_046683 is closely related to the prognosis of MM. It was also detected in tumor cell lines KM3, U266, especially in drug-resistant cell lines KM3/BTZ and MM1R. The NR_046683 expression differed significantly in patients of different MM subtypes and staging. Moreover, the overexpression of NR-046683 is closely related to β-microglobulin. We also found that the overexpression of NR-046683 correlates to chromosomal aberrations, such as del(13q14), gain 1q21, and t(4;14). lncRNA NR_046683 can serve as a novel biomarker for potential drug target and prognostic prediction in MM.
研究长链非编码RNA（lncRNA）NR_046683在多发性骨髓瘤（MM）中的预后价值。采用高通量lncRNA芯片结合生物信息学技术筛选MM中差异表达的lncRNA。采用qRT-PCR检测MM患者和对照中目标lncRNA的表达。首次发现lncRNA NR_046683与MM的预后密切相关。在肿瘤细胞系KM3、U266中也检测到，尤其是在耐药细胞系KM3/BTZ和MM1R中。NR_046683在不同MM亚型和分期患者中的表达差异显著。此外，NR-046683的过表达与β2微球蛋白密切相关。我们还发现NR-046683的过表达与染色体畸变相关，如del(13q14)、1q21增益和t(4;14)。lncRNA NR_046683可作为MM潜在药物靶点和预后预测的新型生物标志物。
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