几种生物标志物对中非地区非传染性疾病病例的诊断效能

Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans.

作者信息

Businge Charles Bitamazire, Longo-Mbenza Benjamin, Adeniyi Oladele Vincent, Muaka Moise Mvitu, Lelo Georges Mvumbi, Nkanga Mireille Solange Nganga, Kavembe Jean-Marie, Buassa-Bu-Tsumbu Baudoin, Kabangu Jean-Rene' M'buyamba, Ter Goon Daniel

机构信息

Walter Sisulu University, Faculty of Health Sciences, Mthatha, South Africa.

Walter Sisulu University, Faculty of Health Sciences, East London, South Africa.

出版信息

Afr Health Sci. 2018 Dec;18(4):909-916. doi: 10.4314/ahs.v18i4.9.

DOI:10.4314/ahs.v18i4.9

PMID:30766554

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6354856/

Abstract

BACKGROUND

This study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.

METHODS

This case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January - December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Anthropometric parameters and blood pressure were measured while blood samples were assayed for biomarkers. The receiver operating characteristics curve and the logistic regression model were applied.

RESULTS

Serum selenium (Se) had specificity and sensitivity of 72.4% and 91.1%, respectively with an area under the curve (AUC) of 0.802; Nitric oxide (NO) (specificity: 72.4%; sensitivity: 93.0%) (AUC = 0.800); Thyroid stimulating hormone (TSH) levels > 6 Mu/L (specificity: 75%; sensitivity: 65%) (AUC = 0.0.727); serum calcium levels of ≥ 110g/L (specificity: 76%; sensitivity: 75%) (AUC = 0.822); and daily salt intake of ≥10 g/day (specificity: 75%; sensitivity: 67%) (AUC = 0.653) in the diagnosis of all NCDs, which were all highly significant (<0.0001).

CONCLUSION

Serum Se, NO, calcium, TSH and daily salt intake had high diagnostic performance as biomarkers for identification of patients with concurrent NCDs in the study population.

摘要

背景

本研究确定了用于中非人非传染性疾病（NCDs）综合诊断的新生物标志物的诊断性能。

方法

本病例对照研究于2008年1月至12月在刚果民主共和国金沙萨的洛莫医疗中心进行。病例包括226名同时患有至少两种或更多种非传染性疾病的参与者。测量人体测量参数和血压，同时检测血样中的生物标志物。应用了受试者工作特征曲线和逻辑回归模型。

结果

血清硒（Se）的特异性和敏感性分别为72.4%和91.1%，曲线下面积（AUC）为0.802；一氧化氮（NO）（特异性：72.4%；敏感性：93.0%）（AUC = 0.800）；促甲状腺激素（TSH）水平>6 Mu/L（特异性：75%；敏感性：65%）（AUC = 0.727）；血清钙水平≥110g/L（特异性：76%；敏感性：75%）（AUC = 0.822）；以及每日盐摄入量≥10 g/天（特异性：75%；敏感性：67%）（AUC = 0.653）用于所有非传染性疾病的诊断，所有这些均具有高度显著性（<0.0001）。