Gombeau Kewin, de Oliveira Ricardo Bezerra, Sarrazin Sandra Layse Ferreira, Mourão Rosa Helena Veras, Bourdineaud Jean-Paul
University of Bordeaux, CNRS, UMR 5805, EPOC, Arcachon Marine Station, 33120 Arcachon, France.
Federal University of Western Pará - UFOPA, PPGRNA, LABBEX, Tapajós Campus, Rua Vera Paz s/n, Bairro Salé, CEP, 68040-050, Caranazal, 88040-060 Santarém, Pará, Brazil.
Toxicol Res. 2019 Jan;35(1):25-35. doi: 10.5487/TR.2019.35.1.025. Epub 2018 Jan 15.
The extracts of and are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast , and against mercurial contamination in zebrafish . In yeast, both extracts efficiently protected the Δ mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.
[具体植物名称1]和[具体植物名称2]的提取物在民间医学中被广泛使用。已经评估了这些提取物对酵母[具体酵母名称]中镉的潜在保护作用，以及对斑马鱼中汞污染的潜在保护作用。在酵母中，两种提取物都能有效保护暴露于氯化镉的Δ突变株，恢复其生长、应激反应基因的表达并降低氧化应激水平。在斑马鱼中，用两种植物提取物补充受甲基汞污染的饲料同样能保护鱼类，通过抑制甲基汞诱导的脂质过氧化、降低乙酰胆碱酯酶活性以及恢复应激反应基因的表达水平。这项研究特别证明了两种水提取物对甲基汞的保护潜力，并且可能为亚马逊地区以鱼为食的社区应对长期接触受污染饮食的影响提供一个有趣的替代方案。
