Kang Mi Hyun, Kim Bae-Hwan
Major in Public Health, Faculty of Food and Health Sciences, Keimyung University, Daegu, Korea.
Toxicol Res. 2018 Apr;34(2):97-102. doi: 10.5487/TR.2018.34.2.097. Epub 2018 Apr 15.
The objective of this study was to determine the oral wound healing effects of acai berry water extracts (ABWE) in rat oral mucosa. To estimate the anti-oxidative effects of ABWE, the contents of phenolic compounds, and DPPH (1,1-diphenyl-2-picryl hydrazyl) and ABTS (2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)) abilities were evaluated. Wound healing effects of ABWE were tested following 6-day exposure after induction of wound by applying 50% acetic acid to oral mucosa of Sprague-Dawley rats. Macroscopic and histopathological analyses were performed to determine wound healing effects of ABWE. Sodium fusidate (20 mg/g) was used as positive control. ABWE showed significantly high antioxidant effects in all assays, although its potency was weaker than the positive control. From day 3 after treatment, wound healing effects of ABWE were observed in oral mucosa. These wound healing effects were also consistent with histopathological evaluation results. Taken together, these results indicate that ABWE might have potential as an oral wound healing agent in the future.
本研究的目的是确定阿萨伊浆果水提取物（ABWE）对大鼠口腔黏膜伤口愈合的影响。为评估ABWE的抗氧化作用，对酚类化合物含量、1,1-二苯基-2-苦基肼（DPPH）和2,2'-联氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）清除能力进行了评估。通过向Sprague-Dawley大鼠口腔黏膜涂抹50%乙酸诱导伤口，在暴露6天后测试ABWE的伤口愈合效果。进行宏观和组织病理学分析以确定ABWE的伤口愈合效果。夫西地酸钠（20mg/g）用作阳性对照。ABWE在所有试验中均显示出显著的高抗氧化作用，尽管其效力弱于阳性对照。治疗后第3天起，在口腔黏膜中观察到ABWE的伤口愈合效果。这些伤口愈合效果也与组织病理学评估结果一致。综上所述，这些结果表明ABWE未来可能具有作为口腔伤口愈合剂的潜力。
