Ergan Esra, Ozturk Faruk, Beyazyildiz Emrullah, Elgin Ufuk, Sen Emine, Cankaya Ali Bulent, Celik Tugrul
Department of Ophthalmology, Amasya University, Sabuncuoglu Serefeddin Research and Training Hospital, Amasya 05200, Turkey.
Department of Ophthalmology, Hacettepe University, Ankara 06230, Turkey.
Int J Ophthalmol. 2016 Feb 18;9(2):249-52. doi: 10.18240/ijo.2016.02.12. eCollection 2016.
To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma.
The prospective study was composed of a study group (n=31) and a control group (n=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels.
Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG.
High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.
评估青光眼患者房水中的总抗氧化状态（TAS）、总氧化状态（TOS）及氧化应激指数（OSI）。
该前瞻性研究由一个研究组（n = 31）和一个对照组（n = 31）组成。研究组中15例患者被诊断为原发性开角型青光眼（POAG），16例患者被诊断为剥脱性青光眼（PEG）。对照组由非青光眼性白内障患者组成。收集房水样本并分析其TAS、TOS和OSI水平。
青光眼患者的房水平均TAS水平显著高于对照组（P<0.01）。青光眼患者的平均TOS和OSI水平有升高趋势。POAG患者和PEG患者之间的TAS、TOS或OSI水平未观察到显著差异。
青光眼患者中观察到高水平的TAS，这可能是对这些患者中观察到的氧化应激增加的一种反应。
