青光眼患者房水中的氧化/抗氧化平衡
Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma.
作者信息
Ergan Esra, Ozturk Faruk, Beyazyildiz Emrullah, Elgin Ufuk, Sen Emine, Cankaya Ali Bulent, Celik Tugrul
机构信息
Department of Ophthalmology, Amasya University, Sabuncuoglu Serefeddin Research and Training Hospital, Amasya 05200, Turkey.
Department of Ophthalmology, Hacettepe University, Ankara 06230, Turkey.
出版信息
Int J Ophthalmol. 2016 Feb 18;9(2):249-52. doi: 10.18240/ijo.2016.02.12. eCollection 2016.
Abstract
AIM
To evaluate total antioxidant status (TAS), total oxidant status (TOS), and the oxidative stress index (OSI) of the aqueous humor (AH) in patients with glaucoma.
METHODS
The prospective study was composed of a study group (n=31) and a control group (n=31). Fifteen patients in the study group were diagnosed with primary open angle glaucoma (POAG), and 16 patients were diagnosed with pseudoexfoliation glaucoma (PEG). The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels.
RESULTS
Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group (P<0.01). Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG.
CONCLUSION
High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.
摘要
目的
评估青光眼患者房水中的总抗氧化状态（TAS）、总氧化状态（TOS）及氧化应激指数（OSI）。
方法
该前瞻性研究由一个研究组（n = 31）和一个对照组（n = 31）组成。研究组中15例患者被诊断为原发性开角型青光眼（POAG），16例患者被诊断为剥脱性青光眼（PEG）。对照组由非青光眼性白内障患者组成。收集房水样本并分析其TAS、TOS和OSI水平。
结果
青光眼患者的房水平均TAS水平显著高于对照组（P<0.01）。青光眼患者的平均TOS和OSI水平有升高趋势。POAG患者和PEG患者之间的TAS、TOS或OSI水平未观察到显著差异。
结论
青光眼患者中观察到高水平的TAS，这可能是对这些患者中观察到的氧化应激增加的一种反应。
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本文引用的文献
1
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Jpn J Ophthalmol. 2014 Jul;58(4):353-8. doi: 10.1007/s10384-014-0325-5. Epub 2014 May 27.
2
[Effect of intraocular pressure on glaucomatous damage to the optic nerve].[眼压对视神经青光眼性损害的影响]
Ophthalmologe. 2014 Feb;111(2):181-8; quiz 189-90. doi: 10.1007/s00347-013-3006-8.
3
Preventative effects of Ginkgo biloba extract (EGb761) on high glucose-cultured opacity of rat lens.银杏叶提取物（EGb761）对高糖培养大鼠晶状体混浊的预防作用。
Phytother Res. 2014 May;28(5):767-73. doi: 10.1002/ptr.5060. Epub 2013 Sep 2.
4
Changes of total antioxidant capacity and total oxidant status of aqueous humor in diabetes patients and correlations with diabetic retinopathy.糖尿病患者房水总抗氧化能力和总氧化剂状态的变化及其与糖尿病视网膜病变的相关性。
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5
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9
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Diabetes Res Clin Pract. 2013 Apr;100(1):69-73. doi: 10.1016/j.diabres.2013.01.018. Epub 2013 Feb 27.
10
Oxidative stress and anti-oxidative defence in patients with age-related macular degeneration.年龄相关性黄斑变性患者的氧化应激和抗氧化防御。
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