He Haisheng, Lu Yi, Qi Jianping, Zhu Quangang, Chen Zhongjian, Wu Wei
Key Laboratory of Smart Drug Delivery of MOE and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China.
Shanghai Dermatology Hospital, Shanghai 200443, China.
Acta Pharm Sin B. 2019 Jan;9(1):36-48. doi: 10.1016/j.apsb.2018.06.005. Epub 2018 Jun 20.
Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.
脂质体模拟天然细胞膜，由于其出色的包封能力、生物相容性和安全性，长期以来一直被作为药物载体进行研究。尽管肠胃外脂质体取得了成功，但脂质体的口服给药受到各种障碍的阻碍，如胃肠道中的不稳定性、跨越生物膜的困难以及大规模生产问题。通过调节脂质双层的组成并添加聚合物或配体，可以大大提高脂质体在口服药物递送方面的稳定性和渗透性。本文综述了脂质体口服递送面临的挑战和当前的方法。
