Jin Na, Zhang Qing, Yang Manyi, Yang Mingying
Institute of Applied Bioresource, College of Animal Sciences, Zhejiang University, Zhejiang, Hangzhou, People's Republic of China.
School of Materials Science and Engineering, Zhejiang University, Zhejiang, Hangzhou, People's Republic of China.
Microsc Res Tech. 2019 Jun;82(6):670-679. doi: 10.1002/jemt.23213. Epub 2019 Feb 14.
Gold nanorods (AuNRs) have attracted widespread attention in the last few decades due to their potential applications in cancer photothermal therapy (CPTT). However, the utilization of AuNRs is restricted because of their high toxicity for cells and tissues. Numerous methods have been developed to solve this problem, among which the most convenient one is to coat AuNRs with biocompatible materials or replace their original toxic surfactant such as the hexadecyl-trimethyl ammonium bromide (CTAB). Organic polymers (OPs) are intensively researched due to their low toxicity and easy access to modification with functional groups (e.g., targeting molecules), pharmaceuticals (e.g., chemo drugs) and imaging agents (e.g., radioactive elements). Herein, this mini review summarized recent progress in detoxification and functionalization of AuNRs exploiting OPs coatings and their applications in CPTT. To begin with, we introduced current major approaches used to modify AuNRs with typical OPs. Then, applications of OPs coated AuNRs in CPTT were discussed. At the end of the review, we proposed a brief outlook for the future development of modification and functionalization of AuNRs with organic materials.
在过去几十年中，金纳米棒（AuNRs）因其在癌症光热疗法（CPTT）中的潜在应用而受到广泛关注。然而，由于AuNRs对细胞和组织具有高毒性，其应用受到限制。人们已经开发了许多方法来解决这个问题，其中最简便的方法是用生物相容性材料包覆AuNRs或替换其原有的有毒表面活性剂，如十六烷基三甲基溴化铵（CTAB）。有机聚合物（OPs）因其低毒性以及易于通过官能团（如靶向分子）、药物（如化疗药物）和成像剂（如放射性元素）进行修饰而受到深入研究。在此，这篇综述总结了利用OPs包覆对AuNRs进行解毒和功能化的最新进展及其在CPTT中的应用。首先，我们介绍了目前用典型OPs修饰AuNRs的主要方法。然后，讨论了OPs包覆的AuNRs在CPTT中的应用。在综述结尾，我们对用有机材料对AuNRs进行修饰和功能化的未来发展提出了简要展望。
