Britton Gabrielle B, O'Bryant Sid E, Johnson Leigh A, Hall James R, Villarreal Alcibiades E, Oviedo Diana C, Pérez-Lao Ambar R, Carreira María B
Neurosciences Center and Clinical Research Unit, Institute of Scientific Research and High Technology Services (INDICASAT AIP), City of Knowledge, Panama.
University of North Texas Health Science Center, Department of Pharmacology & Neuroscience, Fort Worth, TX, United States.
Curr Aging Sci. 2019;11(4):236-241. doi: 10.2174/1874609812666190215125104.
Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.
The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.
Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events.
Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls.
There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.
跌倒在老年人中很常见，并且是住院、入住养老院和死亡的预测因素。
本研究的目的是在一组西班牙裔老年成年人样本中，研究血液炎症标志物与跌倒事件之间的关系。
从参加巴拿马衰老研究倡议项目的190名参与者中收集数据，这些参与者完成了基线临床和认知评估。采集非空腹血样。自我报告的跌倒被分类为在基线评估前12个月内无跌倒、单次跌倒或反复跌倒（两次或更多次）。测量血清C反应蛋白（CRP）、T淋巴细胞分泌蛋白（I-309）、白细胞介素10（IL-10）、白细胞介素6（IL-6）和白细胞介素7（IL-7）的水平。用简易精神状态检查表评估整体认知，用老年抑郁量表（GDS-30）评估抑郁症状。采用多项逻辑回归评估炎症与跌倒事件之间的联系。
抑郁症状、日常生活工具性活动（IADL）受限、IL-7和I-309与跌倒事件显著相关。IL-7水平升高增加了单次跌倒和反复跌倒的可能性，而I-309水平升高仅与反复跌倒相关。IADL受限程度越高和抑郁症状越严重，反复跌倒的可能性就越大。
目前缺乏关于炎症生物标志物与跌倒事件之间关系的研究。这些结果为西班牙裔老年人跌倒的危险因素提供了证据，并可指导公共卫生专业人员制定临床指南以降低跌倒风险。
