Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301, Yanchang Road, Shanghai, China.
School of Medicine, Tongji University, No. 1239, Siping Road, Shanghai, China.
J Transl Med. 2019 Feb 15;17(1):46. doi: 10.1186/s12967-019-1794-6.
Although previous prevalence studies of DED were reported from some countries worldwide, national data are unavailable in China. We aimed to conduct an up-to-date national survey on the prevalence of DED in China and find out the potential risk factors including air pollutant.
23,922 eligible outpatients were recruited from ophthalmic clinics of 32 cities in China in 2013 by registration orders. The patients' demographic characteristics, history of keratorefractive surgery, diseases and medication history were collected and the daily air pollutant data in 2013. Multivariate logistic analysis was performed to identify the potential risk factors associated with DED. The association between related factors and dry eye diseases subtypes evaluated as p value and odds ratios (OR) with 95% confidence intervals (CI).
Among 23,922 outpatients, the prevalence of DED was 61.57%, and that of the male patients was 57.64% and of the female was 65.32% (P < 0.0001). Multivariate logistic regression suggested that the possible risk factors for DED included: female, older age, history of keratorefractive surgery, presence of arthritis, thyroid diseases, and antihistamine, diuretic, duodenal ulcer drugs, diazepam. Air pollutants including O, PM, and SO were also identified as the risk factors.
The prevalence of DED among ophthalmic outpatients in China was considerably high. Age, gender, history of keratorefractive surgery, diseases, medication history, and air pollutants were associated with DED prevalence.
尽管以前有来自世界一些国家的干眼（DED）患病率研究报告，但中国还没有全国性的数据。我们旨在对中国的 DED 患病率进行一项最新的全国性调查，并找出潜在的危险因素，包括空气污染物。
2013 年，通过挂号顺序，从中国 32 个城市的眼科诊所招募了 23922 名合格的门诊患者。收集了患者的人口统计学特征、角膜屈光手术史、疾病和用药史以及 2013 年的日常空气污染物数据。采用多变量逻辑分析来确定与 DED 相关的潜在危险因素。评估相关因素与干眼疾病亚型之间的关联，以 P 值和 95%置信区间（CI）表示比值比（OR）。
在 23922 名门诊患者中，DED 的患病率为 61.57%，男性为 57.64%，女性为 65.32%（P<0.0001）。多变量逻辑回归表明，DED 的可能危险因素包括：女性、年龄较大、角膜屈光手术史、关节炎、甲状腺疾病以及抗组胺药、利尿剂、十二指肠溃疡药物、地西泮。包括 O、PM 和 SO 在内的空气污染物也被确定为危险因素。
中国眼科门诊患者的 DED 患病率相当高。年龄、性别、角膜屈光手术史、疾病、用药史和空气污染物与 DED 患病率相关。
