1York University, School of Kinesiology and Health Science, Toronto, ON, CANADA; and 2LMC Diabetes and Endocrinology and Manna Research, Toronto, ON, CANADA.
Med Sci Sports Exerc. 2017 Mar;49(3):403-412. doi: 10.1249/MSS.0000000000001135.
Prediabetes is linked to several modifiable risk factors, in particular, physical activity participation. The optimal prescription for physical activity remains uncertain. This pilot study aimed to investigate the effectiveness of continuous moderate intensity (CON) versus high-intensity interval training (HIIT) in persons with prediabetes. Outcome measures included glycated hemoglobin (A1C), body composition, musculoskeletal and aerobic fitness.
Participants (n = 35) were recruited and screened using a questionnaire plus capillary blood point-of-care A1C analysis. After baseline screening/exclusions, 21 participants were randomly assigned to either HIIT or CON training three times per week for 12 wk. All participants also undertook resistance training two times per week. A1C, an oral glucose tolerance test, select measures of physical and physiological fitness were assessed at baseline and follow-up.
There were no significant differences in improvements in select metabolic indicators to training between CON and HIT groups. Pooled participant data showed a mean reduction in A1C of 0.5% (95% confidence interval [CI] = 0.3%-0.7%), whereas β-cell function (%β) improved by 28.9% (95% CI = 16.5%-39.2%) and insulin sensitivity (%S) decreased by 34.8 (95% CI = 57.8%-11.8), as assessed by the Homeostatic Model Assessment. Significant reductions in waist circumference of 4.5 cm (P < 0.001) and a 20% (P < 0.001) improvement in aerobic fitness were also observed in both training groups.
The completion of a 12-wk exercise program involving both resistance training and either HIIT or CON training results in improved glycemic control, visceral adiposity, and aerobic fitness in persons with prediabetes.
前驱糖尿病与几个可改变的风险因素有关，特别是身体活动参与度。身体活动的最佳方案仍不确定。本初步研究旨在调查前驱糖尿病患者连续进行中等强度（CON）与高强度间歇训练（HIIT）的效果。主要结果指标包括糖化血红蛋白（A1C）、身体成分、肌肉骨骼和有氧健身。
通过问卷调查和毛细血管点护理 A1C 分析对参与者（n = 35）进行招募和筛选。在基线筛查/排除后，21 名参与者随机分为 HIIT 或 CON 训练组，每周训练 3 次，共 12 周。所有参与者还每周进行两次阻力训练。在基线和随访时评估 A1C、口服葡萄糖耐量试验和部分身体和生理适应性指标。
CON 和 HIIT 组之间的代谢指标改善在训练方面没有显著差异。合并参与者数据显示，A1C 平均降低 0.5%（95%置信区间[CI] = 0.3%-0.7%），而β细胞功能（%β）提高 28.9%（95%CI = 16.5%-39.2%），胰岛素敏感性（%S）降低 34.8%（95%CI = 57.8%-11.8%），通过稳态模型评估得出。在两组训练中，腰围均显著减少 4.5 厘米（P < 0.001），有氧健身能力提高 20%（P < 0.001）。
完成一项包含阻力训练和 HIIT 或 CON 训练的 12 周运动计划可改善前驱糖尿病患者的血糖控制、内脏脂肪堆积和有氧健身能力。
