An efficient genomic signature ranking method for genomic island prediction from a single genome.

Genomic islands that are associated with microbial adaptations and carry genomic signatures different from that of the host, and thus many methods have been proposed to select the informative genomic signatures from a range of organisms and discriminate genomic islands from the rest of the genome in terms of these signature biases. However, they are of limited use when closely related genomes are unavailable. In the present work, we proposed a kurtosis-based ranking method to select the informative genomic signatures from a single genome. In simulations with alien fragments from artificial and real genomes, the proposed kurtosis-based ranking method efficiently selected the informative genomic signatures from a single genome, without annotated information of genomes or prior knowledge from other datasets. This understanding can be useful to design more powerful method for genomic island detection.