N.P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia; Department of Neuropsychology, Andrzej Frycz-Modrzewski Krakow University, Krakow, Poland.
N.P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia.
Clin Neurophysiol. 2019 Apr;130(4):445-453. doi: 10.1016/j.clinph.2019.01.015. Epub 2019 Feb 10.
The main goal was to assess common and specific deficits of cognitive control in (Attention Deficit Hyperactivity Disorder) ADHD and schizophrenia (SZ) using event-related potentials (ERPs).
Behavioral and EEG data in cued GO/NOGO task were recorded in 132 healthy controls (HC) and age, gender and education matched 63 ADHD adults, and 68 SZ patients.
N2d wave in NOGO-GO contrast of ERPs did not differ between the groups while the P3d wave discriminated SZ group from two other groups. Latent components of ERPs were extracted by blind source separation method based on second-order statistics Kropotov et al. (2017) and compared between the groups. A counterpart of N2d wave of a frontally distributed latent component was smaller in SZ indicating a specific frontal dysfunction of conflict detection in SZ. Two centrally distributed P3 sub-components were reduced in both groups indicating a non-specific dysfunction of action inhibition operations in ADHD and SZ.
A pattern of specific and common dysfunctions in terms of latent ERP components shows a more complex picture of functional impairment in schizophrenia and ADHD in comparison to conventional N2/P3 ERP description.
The latent component approach shows a functionally different pattern of cognitive control impairment in comparison to the conventional ERP analysis.
本研究旨在使用事件相关电位（ERP）评估注意缺陷多动障碍（ADHD）和精神分裂症（SZ）中认知控制的常见和特定缺陷。
在 132 名健康对照者（HC）和年龄、性别和教育程度匹配的 63 名 ADHD 成人以及 68 名 SZ 患者中，记录了线索 GO/NOGO 任务中的行为和 EEG 数据。
ERP 的 NOGO-GO 对比中 N2d 波在组间无差异，而 P3d 波可区分 SZ 组与其他两组。基于二阶统计 Kropotov 等人（2017）的盲源分离方法提取了 ERP 的潜在成分，并在组间进行了比较。在 SZ 中，一个额部分布的潜在成分的 N2d 波的对应物较小，表明 SZ 中冲突检测的特定额叶功能障碍。两组 P3 子成分均减少，表明 ADHD 和 SZ 中动作抑制操作的非特异性功能障碍。
就潜在 ERP 成分而言，特定和常见功能障碍的模式表明，与传统的 N2/P3 ERP 描述相比，精神分裂症和 ADHD 的功能损伤呈现出更为复杂的情况。
与传统 ERP 分析相比，潜在成分方法显示出认知控制损伤的功能不同模式。
