Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Nat Rev Immunol. 2019 Apr;19(4):205-217. doi: 10.1038/s41577-019-0131-x.
Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Here, we discuss recent efforts in the field of systems immunology to bring about a quantitative understanding of cytokine-mediated communication between leukocytes and to provide novel insights into the orchestration of immune responses and inflammation.
细胞因子介导的细胞间通讯是免疫系统细胞相互交流的主要机制。在结构、生物物理、生化和细胞水平上，免疫系统中细胞因子信号转导的许多方面都已经得到了深入的研究。然而，对于控制细胞因子介导的细胞间通讯的定量规则，我们仍然缺乏系统的理解。在这里，我们讨论了系统免疫学领域的最新努力，以实现对白细胞之间细胞因子介导的通讯的定量理解，并为免疫反应和炎症的协调提供新的见解。
