Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Univ-Lyon, Inserm UMR 1060, Inra UMR 1397, INSA-Lyon, IMBL, 20 Ave A., Einstein, 69100 Villeurbanne, France.
Prostaglandins Leukot Essent Fatty Acids. 2019 Mar;142:1-3. doi: 10.1016/j.plefa.2018.12.003. Epub 2018 Dec 25.
The brain requires a constant supply of docosahexaenoic acid (DHA) from blood to maintain DHA levels within the brain. Several plasma pools have been proposed to supply the brain with DHA, including plasma lipoproteins, lysophosphatidylcholine and unesterified fatty acids. Here we briefly review the evidence for each plasma pool supplying the brain highlighting controversies and remaining questions. We conclude that circulating lysophosphatidylcholine has a higher brain/body partition coefficient than unesterified DHA while unesterified DHA entry into the brain is more rapid.
大脑需要从血液中不断获得二十二碳六烯酸（DHA）以维持大脑内的 DHA 水平。有几种血浆池被提出可以为大脑提供 DHA，包括血浆脂蛋白、溶血磷脂酰胆碱和非酯化脂肪酸。在这里，我们简要回顾了每种为大脑提供 DHA 的血浆池的证据，突出了争议和遗留问题。我们得出结论，与非酯化的 DHA 相比，循环溶血磷脂酰胆碱进入大脑的速度更快，大脑/身体分配系数更高。
