Gao Dingcheng, Mittal Vivek, Ban Yi, Lourenco Ana Rita, Yomtoubian Shira, Lee Sharrell
Department of Cardiothoracic Surgery, Department of Cell and Developmental Biology, Neuberger Berman Lung Cancer Center, Weill Cornell Medicine, New York, NY10065, USA.
Front Biol (Beijing). 2018 Aug;13(4):277-286. doi: 10.1007/s11515-018-1513-3. Epub 2018 Aug 20.
Metastasis is the primary cause of mortality in cancer patients. Therefore, elucidating the genetics and epigenetics of metastatic tumor cells and the mechanisms by which tumor cells acquire metastatic properties constitute significant challenges in cancer research.
To summarize the current understandings of the specific genotype and phenotype of the metastatic tumor cells.
In-depth genetic analysis of tumor cells, especially with advances in the next-generation sequencing, have revealed insights of the genotypes of metastatic tumor cells. Also, studies have shown that the cancer stem cell (CSC) and epithelial to mesenchymal transition (EMT) phenotypes are associated with the metastatic cascade.
In this review, we will discuss recent advances in the field by focusing on the genomic instability and phenotypic dynamics of metastatic tumor cells.
转移是癌症患者死亡的主要原因。因此，阐明转移性肿瘤细胞的遗传学和表观遗传学以及肿瘤细胞获得转移特性的机制是癌症研究中的重大挑战。
总结目前对转移性肿瘤细胞特定基因型和表型的认识。
对肿瘤细胞进行深入的遗传分析，尤其是随着下一代测序技术的进步，已经揭示了转移性肿瘤细胞基因型的相关见解。此外，研究表明癌症干细胞（CSC）和上皮-间质转化（EMT）表型与转移级联相关。
在本综述中，我们将通过关注转移性肿瘤细胞的基因组不稳定性和表型动态来讨论该领域的最新进展。
