Jerzykiewicz Julia, Czogalla Aleksander
Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, Fryderyka Joliot-Curie 14a, 50-383 Wroclaw, Poland.
Materials (Basel). 2021 Dec 27;15(1):179. doi: 10.3390/ma15010179.
Recent years have witnessed rapidly growing interest in application of gene therapies for cancer treatment. However, this strategy requires nucleic acid carriers that are both effective and safe. In this context, non-viral vectors have advantages over their viral counterparts. In particular, lipopolyplexes-nanocomplexes consisting of nucleic acids condensed with polyvalent molecules and enclosed in lipid vesicles-currently offer great promise. In this article, we briefly review the major aspects of developing such non-viral vectors based on polyethyleneimine and outline their properties in light of anticancer therapeutic strategies. Finally, examples of current in vivo studies involving such lipopolyplexes and possibilities for their future development are presented.
近年来，基因疗法在癌症治疗中的应用受到了迅速增长的关注。然而，这种策略需要有效且安全的核酸载体。在这种情况下，非病毒载体相对于病毒载体具有优势。特别是，脂聚复合物——由与多价分子凝聚并包裹在脂质囊泡中的核酸组成的纳米复合物——目前具有很大的前景。在本文中，我们简要回顾了基于聚乙烯亚胺开发此类非病毒载体的主要方面，并根据抗癌治疗策略概述了它们的特性。最后，介绍了目前涉及此类脂聚复合物的体内研究实例及其未来发展的可能性。
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