Puyo Léo, Paques Michel, Fink Mathias, Sahel José-Alain, Atlan Michael
Institut Langevin, Centre National de la Recherche Scientifique (CNRS), Paris Sciences & Lettres (PSL University), École Supérieure de Physique et de Chimie Industrielles (ESPCI Paris), 1 rue Jussieu, 75005 Paris, France.
Paris Adaptive Optics, Retinal Imaging, and Surgery, (PARIS) Group, France.
Biomed Opt Express. 2019 Jan 31;10(2):995-1012. doi: 10.1364/BOE.10.000995. eCollection 2019 Feb 1.
The choroid is a highly vascularized tissue supplying the retinal pigment epithelium and photoreceptors. Its implication in retinal diseases is gaining increasing interest. However, investigating the anatomy and flow of the choroid remains challenging. Here we show that laser Doppler holography provides high-contrast imaging of choroidal vessels in humans, with a spatial resolution comparable to state-of-the-art indocyanine green angiography and optical coherence tomography. Additionally, laser Doppler holography contributes to sort out choroidal arteries and veins by using a power Doppler spectral analysis. We thus demonstrate the potential of laser Doppler holography to improve our understanding of the anatomy and flow of the choroidal vascular network.
脉络膜是一种高度血管化的组织，为视网膜色素上皮和光感受器提供营养。其在视网膜疾病中的作用越来越受到关注。然而，研究脉络膜的解剖结构和血流仍然具有挑战性。在这里，我们表明激光多普勒全息术能够对人体脉络膜血管进行高对比度成像，其空间分辨率与最先进的吲哚菁绿血管造影术和光学相干断层扫描相当。此外，激光多普勒全息术通过功率多普勒频谱分析有助于区分脉络膜动脉和静脉。因此，我们证明了激光多普勒全息术在增进我们对脉络膜血管网络的解剖结构和血流理解方面的潜力。
