Department of Diabetes and Metabolism, Ise Red Cross Hospital, Mie, Japan.
J Diabetes Res. 2019 Jan 15;2019:4684815. doi: 10.1155/2019/4684815. eCollection 2019.
In the present study, we aimed to investigate the effects of continuous glucose monitoring (CGM) on blood glucose levels, body weight, blood pressure, and hypoglycaemia in patients with type 2 diabetes mellitus using a meta-analysis of randomized controlled trials (RCTs). A literature search was performed using MEDLINE, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. RCTs using CGM in patients with type 2 diabetes mellitus were then selected. Statistical analysis included calculation of the standardized mean difference (SMD) or risk ratio and 95% confidence intervals (CIs) using a random effects model. After literature search, seven RCTs (669 patients) satisfied the eligibility criteria established herein and were included into the meta-analysis. Compared with the self-monitoring blood glucose group, the CGM group exhibited significantly lower HbA1c levels (SMD, -0.35; 95% CI, -0.59--0.10; = 0.006) and shorter time spent with hypoglycaemia (SMD, -0.42; 95% CI, -0.70--0.13; = 0.004). Conversely, no differences in body weight and blood pressure were observed between the groups. CGM in patients with type 2 diabetes mellitus could reduce HbA1c levels and time spent with hypoglycaemia. However, because few RCTs were included in this present study and heterogeneity was also noted, care should be taken when interpreting the results.
在本研究中，我们旨在通过对随机对照试验（RCT）的荟萃分析，研究连续血糖监测（CGM）对 2 型糖尿病患者血糖水平、体重、血压和低血糖的影响。使用 MEDLINE、Cochrane 对照试验注册中心和 ClinicalTrials.gov 进行文献检索。然后选择使用 CGM 治疗 2 型糖尿病患者的 RCT。统计分析包括使用随机效应模型计算标准化均数差（SMD）或风险比和 95%置信区间（CI）。文献检索后，有 7 项 RCT（669 名患者）符合本文建立的纳入标准，并纳入荟萃分析。与自我监测血糖组相比，CGM 组的 HbA1c 水平明显降低（SMD，-0.35；95%CI，-0.59--0.10； = 0.006），低血糖时间明显缩短（SMD，-0.42；95%CI，-0.70--0.13； = 0.004）。然而，两组之间的体重和血压没有差异。CGM 可降低 2 型糖尿病患者的 HbA1c 水平和低血糖时间。然而，由于本研究纳入的 RCT 较少，且存在异质性，因此在解释结果时应谨慎。
