Lee Wen Di, Devarajan Kavya, Chua Jacqueline, Schmetterer Leopold, Mehta Jodhbir S, Ang Marcus
1Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
2Eye-ACP, Duke-NUS Graduate Medical School, Singapore, Singapore.
Eye Vis (Lond). 2019 Feb 1;6:4. doi: 10.1186/s40662-019-0129-2. eCollection 2019.
Optical coherence tomography angiography (OCTA) is a rapid and non-invasive technique for imaging vasculature in the eye. As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest, it has become a promising method for anterior segment imaging. Furthermore, OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography. However, conventional OCTA systems are typically designed and optimized for the posterior segment of the eye, and thus using OCTA for anterior segment imaging can present several difficulties and limitations. In this review, we summarized the recent developments and clinical applications in anterior segment OCTA (AS-OCTA) imaging, such as for the cornea, iris, sclera and conjunctiva. We also compared commercially available OCTA systems, discussed the limitations of adapting current OCTA technology for the anterior segment imaging, and proposed possible future directions for AS-OCTA systems. AS-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies, pre-operative surgical planning, assessment of new anti-angiogenic therapeutics or evaluation of limbal stem cell deficiency. With further development, OCTA for anterior segment imaging in the clinics may become common in the near future.
光学相干断层扫描血管造影（OCTA）是一种用于眼部血管成像的快速且非侵入性技术。由于OCTA能够生成高分辨率的横截面图像，并允许进行深度分辨分析以准确确定感兴趣病变的位置，它已成为眼前段成像的一种有前景的方法。此外，与传统的基于染料的侵入性荧光血管造影相比，OCTA对患者更友好。然而，传统的OCTA系统通常是为眼后段设计和优化的，因此将OCTA用于眼前段成像可能会带来一些困难和限制。在本综述中，我们总结了眼前段OCTA（AS - OCTA）成像在角膜、虹膜、巩膜和结膜等方面的最新进展和临床应用。我们还比较了市售的OCTA系统，讨论了将当前OCTA技术应用于眼前段成像的局限性，并提出了AS - OCTA系统未来可能的发展方向。AS - OCTA为未来的临床应用提供了潜力，如角膜和虹膜病变的诊断、术前手术规划、新型抗血管生成疗法的评估或角膜缘干细胞缺乏的评估。随着进一步发展，用于临床眼前段成像的OCTA在不久的将来可能会变得普遍。
