a IRCCS SDN , Naples , Italy.
b Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, U.O.C. Immunohematology , Transfusion Medicine and Transplant Immunology, Azienda Ospedaliera Universitaria, Università degli Studi della Campania 'Luigi Vanvitelli' , Naples , Italy.
Int J Food Sci Nutr. 2019 Sep;70(6):725-737. doi: 10.1080/09637486.2018.1563052. Epub 2019 Feb 18.
This study sought to determine the possible detrimental effects of several low- or non-caloric sweeteners on endothelial progenitor cells (EPCs), inflammation and behavioural changes in mice. C57BL/6 male mice received low and high dose of natural and artificial sweeteners for 4 weeks. EPCs, physical and biochemical variables, inflammation and behavioural changes were evaluated. A significant reduction of about 25% of EPCs was found when mice received a moderate amount of all sweeteners ( < .05). This reduction was more strongly significant when a double dose of glucose, aspartame, rebaudioside A and cyclamate ( < .005) in comparison to fructose and sucrose ( < .05) was administered. During inflammation carrageenan-induced, all sweeteners produced a significant increase of EPCs compared to the control group ( < .05). Consumption of glucose and sugar substitutes affect mouse EPC number according to the absence or presence of an inflammatory status, but does not induce detrimental effects on inflammation and behavioural changes.
本研究旨在确定几种低热量或无热量甜味剂对内皮祖细胞 (EPC)、炎症和行为变化的可能有害影响。C57BL/6 雄性小鼠接受低剂量和高剂量的天然和人工甜味剂 4 周。评估 EPC、生理和生化变量、炎症和行为变化。当小鼠接受适量的所有甜味剂时，EPC 减少约 25%（<0.05）。当给予葡萄糖、阿斯巴甜、莱鲍迪甙 A 和环己胺酸盐的双剂量（<0.005）时，与果糖和蔗糖（<0.05）相比，这种减少更为显著。在炎症性角叉菜胶诱导期间，与对照组相比，所有甜味剂均使 EPC 显著增加（<0.05）。根据是否存在炎症状态，葡萄糖和糖替代品的消耗会影响小鼠 EPC 的数量，但不会对炎症和行为变化产生有害影响。
