Polyák Eva, Gombos K, Hajnal B, Bonyár-Müller K, Szabó Sz, Gubicskó-Kisbenedek A, Marton K, Ember I
Faculty of Health Sciences University of Pécs Department of Nutritional Sciences and Dietetics, Institute of Physiotherapy and Nutritional Sciences Pécs Hungary.
Acta Physiol Hung. 2010 Dec;97(4):401-7. doi: 10.1556/APhysiol.97.2010.4.9.
Artificial sweeteners are widely used all over the world. They may assist in weight management, prevention of dental caries, control of blood glucose of diabetics, and also can be used to replace sugar in foods. In the animal experimentation mice were given oral doses of water solutions of table top artificial sweeteners (saccharin, cyclamate based, acesulfame-K based, and aspartame) the amount of maximum Acceptable Daily Intake (ADI) ad libitum. The controls received only tap water with the same drinking conditions as the treated groups. The mice were fed chow ad libitum.We measured food intake and body weight once a week, water and solutions of artificial sweeteners intake twice a week. The data were analysed by statistical methods (T-probe, regression analysis).Consumption of sweeteners resulted in significantly increased body weight; however, the food intake did not change.These results question the effect of non-caloric artificial sweeteners on weight-maintenance or body weight decrease.
人工甜味剂在全球被广泛使用。它们有助于体重管理、预防龋齿、控制糖尿病患者的血糖，还可用于替代食品中的糖。在动物实验中，给小鼠随意口服相当于最大可接受日摄入量（ADI）的桌面人工甜味剂（糖精、基于环己基氨基磺酸钠的甜味剂、基于乙酰磺胺酸钾的甜味剂和阿斯巴甜）水溶液。对照组仅饮用与处理组相同饮用条件的自来水。小鼠随意进食饲料。我们每周测量一次食物摄入量和体重，每周测量两次水和人工甜味剂溶液的摄入量。数据通过统计方法（T检验、回归分析）进行分析。甜味剂的摄入导致体重显著增加；然而，食物摄入量没有变化。这些结果对无热量人工甜味剂在维持体重或减轻体重方面的效果提出了质疑。
