State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures , Nanjing University , Nanjing 210023 , P. R. China.
ACS Appl Mater Interfaces. 2019 Mar 13;11(10):10389-10398. doi: 10.1021/acsami.8b21424. Epub 2019 Mar 1.
We have developed a green and versatile method to prepare hierarchically porous Cu(BTC)@carboxymethyl chitosan (HKUST-1@CMCS) with a macroscopic shape control and designable performance via the cross-linking of Cu(II) ions with CMCS. Furthermore, atomic force microscopy, scanning electron microscopy, powder X-ray diffraction, Brunauer-Emmett-Teller, and X-ray photoelectron spectroscopy analyses showed that the morphology of HKUST-1 could be controlled and changed by tailoring the surface roughness ( R) of polymer matrix. For the ball-like, fiberlike, and membrane-like composites, the matrix R values were 887, 88.4, and 18.2 nm and the average sizes of HKUST-1 crystals were about 10.2, 5.9, and 1.7 μm, respectively. It was found that the larger the R of the polymer matrix, the higher the drug payload. The results of drug release showed that the release percentage of dimethyl fumarate from HKUST-1@CMCS was 66% in 326 h, whereas that of Cu@CMCS was only 12 h. Obviously, the HKUST-1@CMCS had a long-acting and sustained release property compared to that of Cu@CMCS due to its complementary advantages of metal-organic frameworks (MOFs) and polymers. Therefore, this study not only provided an interesting way to make up for the shortcomings of MOFs and natural polymer but also developed a long-acting delivery system for a huge potential application prospect.
我们开发了一种绿色且多功能的方法，通过 CMCS 与 Cu(II) 离子的交联，制备出具有宏观形状控制和可设计性能的分级多孔 Cu(BTC)@羧甲基壳聚糖（HKUST-1@CMCS）。此外，原子力显微镜、扫描电子显微镜、粉末 X 射线衍射、BET 和 X 射线光电子能谱分析表明，通过调整聚合物基体的表面粗糙度（R）可以控制和改变 HKUST-1 的形态。对于球状、纤维状和膜状复合材料，基体 R 值分别为 887、88.4 和 18.2nm，HKUST-1 晶体的平均尺寸分别约为 10.2、5.9 和 1.7μm。结果发现，聚合物基体的 R 值越大，药物载药量越高。药物释放结果表明，326h 内富马酸二甲酯从 HKUST-1@CMCS 中的释放百分比为 66%，而 Cu@CMCS 仅为 12%。显然，与 Cu@CMCS 相比，由于金属有机骨架（MOFs）和聚合物的互补优势，HKUST-1@CMCS 具有长效和持续释放的特性。因此，该研究不仅提供了一种有趣的方法来弥补 MOFs 和天然聚合物的不足，而且还开发了一种长效递送系统，具有巨大的潜在应用前景。
