Kerezoudi C, Samanidou V F, Gogos C, Tziafas D, Palaghias G
Aristotle University of Thessaloniki.
Eur J Prosthodont Restor Dent. 2019 Feb 22;27(1):10-17. doi: 10.1922/EJPRD_01854Kerezoudi09.
The aim of the study was to evaluate the elution of Triethylene glycol dimethacrylate (TEGDMA), Urethane dimethacrylate (UDMA), Bisphenol A glycerolate dimethacrylate (BisGMA), and Bisphenol A (BPA), from a dual-cured resin cement through human dentin, under constant positive pulpal pressure. Ten human dentin disks were adjusted into a custom made testing device and transparent glass slabs were luted with Variolink II cement, under a steady pressure. The device was filled with Ringer's solution and a pressure of 14.1 cm H₂O was applied. Eluates were retrieved from each one of the ten specimens at 9 time interval. All the samples were analyzed by High Performance Liquid Chromatography (HPLC). TEGDMA was detected from the second and UDMA was detected from the fourth time interval and then. The highest average concentration of TEGDMA and UDMA was detected in the 3 day time interval. Time had a significant effect on their elution. BPA and BisGMA were not detected in any sample of any time interval. The clinical relevance of the present study is that the concentration of the eluted monomers, under the conditions that were chosen, did not reach toxic levels for the pulp.
本研究的目的是评估在恒定的正向牙髓压力下，双固化树脂水门汀中的二甲基丙烯酸三乙二醇酯（TEGDMA）、二甲基丙烯酸聚氨酯（UDMA）、二甲基丙烯酸双酚A甘油酯（BisGMA）和双酚A（BPA）通过人牙本质的洗脱情况。将十个人牙本质圆盘调整到定制的测试装置中，在稳定压力下用Variolink II水门汀粘结透明玻璃板。装置中充满林格氏液，并施加14.1 cm H₂O的压力。在9个时间间隔从十个样本中的每一个中取出洗脱液。所有样品通过高效液相色谱（HPLC）进行分析。从第二个时间间隔开始检测到TEGDMA，从第四个时间间隔开始检测到UDMA，然后一直能检测到。在3天的时间间隔内检测到TEGDMA和UDMA的最高平均浓度。时间对它们的洗脱有显著影响。在任何时间间隔的任何样本中均未检测到BPA和BisGMA。本研究的临床意义在于，在所选择的条件下，洗脱单体的浓度未达到对牙髓有毒的水平。
