Researcher, Department of Dental Tissues Pathology and Therapeutics, Division of Operative Dentistry, Faculty of Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Graduate student, Department of Chemistry, Laboratory of Analytical Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Prosthet Dent. 2020 Feb;123(2):339-348. doi: 10.1016/j.prosdent.2019.01.012. Epub 2019 May 10.
Monomer leaching from restorations may affect the oral mucosa and general health; however, information on monomer leaching from chairside computer-aided design and computer-aided manufacturing (CAD-CAM) restorative materials is lacking.
The purpose of this in vitro study was to investigate the leaching of monomers from newly introduced resin-modified ceramics and composite resin CAD-CAM blocks that were immersed in water and ethanol for short-term and long-term incubation periods.
Ten square-shaped specimens of 5 newly introduced CAD-CAM blocks were suspended by means of a silk thread in distilled water and in 75% ethanol. After 1 day, 7 days, 30 days, and 60 days, the eluates bisphenol A (BPA), urethane dimethacrylate (UDMA), triethylene glycol dimethacrylate (TEGDMA), N, N-dimethylacrylamide (DMA), bisphenol A-glycidyl dimethacrylate (Bis-GMA), and bisphenol A ethoxylate dimethacrylate (Bis-EMA) were analyzed by means of high-performance liquid chromatography (HPLC). Additional specimens of each material, before and after immersion in the solutions, were investigated by scanning electron microscopy, and elemental analysis was performed by energy-dispersive X-ray spectrometry.
TEGDMA and UDMA were the main monomers eluted from all the materials tested. A pattern of declining release was detected for all the monomers. Bisphenol-A was not released by any of the investigated ceramic-composite or composite resin blocks either in water or ethanol.
CAD-CAM blocks release less monomer when they are immersed in aqueous solutions in the short-term and long-term periods than conventional resin composite materials. The amount of monomer release declined until no monomer could be detected.
修复体中的单体浸出可能会影响口腔黏膜和整体健康；然而，关于椅旁计算机辅助设计和计算机辅助制造（CAD-CAM）修复材料单体浸出的信息还很缺乏。
本体外研究的目的是调查在短期和长期孵育期内，浸入水中和乙醇中的新引入的树脂改性陶瓷和复合树脂 CAD-CAM 块中单体的浸出情况。
通过丝线将 10 个 5 种新引入的 CAD-CAM 块的方形样本悬挂在蒸馏水中和 75%乙醇中。在第 1 天、第 7 天、第 30 天和第 60 天，通过高效液相色谱法（HPLC）分析了双酚 A（BPA）、尿烷二甲基丙烯酸酯（UDMA）、三乙二醇二甲基丙烯酸酯（TEGDMA）、N，N-二甲基丙烯酰胺（DMA）、双酚 A-缩水甘油二甲基丙烯酸酯（Bis-GMA）和双酚 A 乙氧基二甲基丙烯酸酯（Bis-EMA）的浸出物。在浸入溶液前后，对每种材料的额外样本进行扫描电子显微镜检查，并通过能量色散 X 射线光谱法进行元素分析。
TEGDMA 和 UDMA 是所有测试材料中主要浸出的单体。所有单体都检测到释放量逐渐减少的模式。在水或乙醇中，没有任何一种被调查的陶瓷-复合或复合树脂块释放出双酚-A。
CAD-CAM 块在短期和长期浸入水溶液中时，释放的单体比传统的树脂复合材料少。单体的释放量减少，直到无法检测到单体。
