Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
PLoS One. 2019 Feb 19;14(2):e0208913. doi: 10.1371/journal.pone.0208913. eCollection 2019.
Emerging studies have shed light on the association between Helicobacter pylori (HP) infection and cardiometabolic risk. However, there is no evidence to support a causal link for the relationship in the general population. Our aim was to determine whether HP infection is associated with the risks of incident type II diabetes mellitus (DM) in a population-based cohort consisting of adults from the general population. A total of 69235 adults enrolled in the study obtained health examinations at the Tri-Service General Hospital in Taiwan from 2010 to 2016. HP infection detection was performed by rapid urease tests (RUTs), and endoscopic examinations were used to diagnose gastroesophageal reflux disease (GERD), gastric ulcers (GUs) and duodenal ulcers (DUs). Cross-sectional and longitudinal analyses were performed to examine the association between HP infection and cardiometabolic diseases using logistic regression and Cox regression in a large population-based study. HP infection was significantly associated with the presence of metabolic syndrome (MetS) (OR = 1.26, 95%CI: 1.00-1.57) and DM (OR = 1.59, 95%CI: 1.17-2.17) only in male subjects, and abnormal endoscopic findings were also correlated with cardiometabolic diseases. Our findings demonstrated that participants with HP infection had an elevated risk of developing incident DM (HR = 1.54, 95%CI: 1.11-2.13). In addition, endoscopic findings of a DU (HR = 1.63, 95%CI: 1.02-2.63), rather than GERD or a GU, were also predictive of incident DM. In this cohort, HP infection was a statistically significant predictor of incident DM among male population.
新的研究揭示了幽门螺杆菌（HP）感染与心脏代谢风险之间的关联。然而，在一般人群中，没有证据支持两者之间存在因果关系。我们的目的是确定在一个由普通人群中的成年人组成的基于人群的队列中，HP 感染是否与新发 2 型糖尿病（DM）的风险相关。共有 69235 名成年人于 2010 年至 2016 年在台湾三军总医院进行了健康检查。通过快速尿素酶试验（RUT）检测 HP 感染，内窥镜检查用于诊断胃食管反流病（GERD）、胃溃疡（GU）和十二指肠溃疡（DU）。在一项大型基于人群的研究中，使用逻辑回归和 Cox 回归进行横断面和纵向分析，以检查 HP 感染与心脏代谢疾病之间的关系。HP 感染与代谢综合征（MetS）（OR=1.26，95%CI：1.00-1.57）和 DM（OR=1.59，95%CI：1.17-2.17）的存在仅在男性受试者中显著相关，异常内窥镜检查结果也与心脏代谢疾病相关。我们的研究结果表明，HP 感染的参与者发生新发 DM 的风险增加（HR=1.54，95%CI：1.11-2.13）。此外，DU 的内镜检查结果（HR=1.63，95%CI：1.02-2.63），而不是 GERD 或 GU，也与新发 DM 相关。在该队列中，HP 感染是男性人群中发生 DM 的一个统计学上显著的预测因子。
