橙皮苷可改善小鼠离体早卵泡 3D 培养中的卵泡发育。
Hesperidin improves the follicular development in 3D culture of isolated preantral ovarian follicles of mice.
机构信息
1 Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran.
2 Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
出版信息
Exp Biol Med (Maywood). 2019 Apr;244(5):352-361. doi: 10.1177/1535370219831615. Epub 2019 Feb 19.
Abstract
It has been stated that hesperidin has many pharmacological effects, such as anti-inflammatory and antioxidant effects, antimicrobial activity, and anti-carcinogenic activity; but hesperidin and its derivatives have been under investigation as anti-fertility factors for a very long time. However, our results show that hesperidin can improve mice follicular growth and maturation during in vitro 3D culture. Hesperidin as an antioxidant factor could enhance the mRNA expression levels of two important genes involved in folliculogenesis, PCNA, and FSH-R. Our results prove for the first time that hesperidin not only has deleterious effects on follicular development but can also increase rates of in vitro fertilization and embryo development.
摘要
有研究表明，橙皮苷具有多种药理作用，如抗炎、抗氧化、抗菌和抗癌作用。但橙皮苷及其衍生物作为抗生育因子的研究由来已久。然而，我们的研究结果表明，橙皮苷可改善体外 3D 培养中小鼠卵泡的生长和成熟。作为一种抗氧化因子，橙皮苷可以提高参与卵泡发生的两个重要基因 PCNA 和 FSH-R 的 mRNA 表达水平。本研究首次证明，橙皮苷不仅对卵泡发育有不良影响，还可以提高体外受精和胚胎发育的效率。
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