Aix Marseille Université, CNRS, LNC UMR 7291, 13331, Marseille, France.
Nat Commun. 2019 Feb 19;10(1):840. doi: 10.1038/s41467-019-08795-w.
Entorhinal grid cells are thought to provide a 2D spatial metric of the environment. In this study we demonstrate that in a familiar 1D circular track (i.e., a continuous space) grid cells display a novel 1D equidistant firing pattern based on integrated distance rather than travelled distance or time. In addition, field spacing is increased compared to a 2D open field, probably due to a reduced access to the visual cue in the track. This metrical modification is accompanied by a change in LFP theta oscillations, but no change in intrinsic grid cell rhythmicity, or firing activity of entorhinal speed and head-direction cells. These results suggest that in a 1D circular space grid cell spatial selectivity is shaped by path integration processes, while grid scale relies on external information.
内嗅皮层网格细胞被认为提供了环境的二维空间度量。在这项研究中，我们证明了在一个熟悉的一维圆形轨道（即连续空间）中，网格细胞基于整合距离而不是行驶距离或时间显示出一种新颖的一维等距发射模式。此外，与二维开阔场相比，场间距增加，可能是由于在轨道中对视觉线索的获取减少。这种度量的修改伴随着 LFPθ 振荡的变化，但内在网格细胞节律性或内嗅速度和头部方向细胞的放电活动没有变化。这些结果表明，在一维圆形空间中，网格细胞的空间选择性是由路径整合过程形成的，而网格尺度则依赖于外部信息。
