Larmo Petra S, Yang Baoru, Hurme Saija A M, Alin Jouni A, Kallio Heikki P, Salminen Eeva K, Tahvonen Raija L
Department of Biochemistry and Food Chemistry, University of Turku, 20014, Turku, Finland.
Eur J Nutr. 2009 Aug;48(5):277-82. doi: 10.1007/s00394-009-0011-4. Epub 2009 Mar 14.
Epidemiological studies indicate beneficial effects of flavonoids on cardiovascular disease (CVD) risk.
To study the effect of flavonoid-rich sea buckthorn berry (SBB) on circulating lipid markers associated with CVD risk and plasma flavonol concentration. Also investigated was whether changes in the circulating flavonol concentrations correlate with the SBB induced changes in C-reactive protein (CRP) concentration observed previously.
In all 229 healthy participants completed the randomized double-blind study and consumed daily 28 g of SBB or placebo for 3 months. Fasting blood samples for the analysis of lipid markers and flavonols were obtained at the beginning and end of the study.
Compared to the placebo, the consumption of SBB increased the plasma concentration of the flavonols quercetin and isorhamnetin significantly [treatment differences 3.0 ng/ml (P = 0.03) and 3.9 ng/ml (P < 0.01), respectively]. The increase of kaempferol concentration was not significant [treatment difference 0.7 ng/ml (P = 0.08)]. SBB did not affect the serum total, HDL, LDL cholesterol, or the serum triacylglycerol concentrations. There was no correlation between the changes in flavonol and CRP concentrations of participants.
The consumption of SBB significantly increased the fasting plasma concentration of quercetin and isorhamnetin indicating that it is a good dietary source of flavonols. However, this did not convert to affecting the circulating concentrations of lipid markers in healthy, normolipidemic adults having healthy diets.
流行病学研究表明黄酮类化合物对心血管疾病（CVD）风险具有有益作用。
研究富含黄酮类化合物的沙棘浆果（SBB）对与CVD风险相关的循环脂质标志物和血浆黄酮醇浓度的影响。此外，还研究了循环黄酮醇浓度的变化是否与先前观察到的SBB诱导的C反应蛋白（CRP）浓度变化相关。
共有229名健康参与者完成了这项随机双盲研究，他们每天食用28克SBB或安慰剂，持续3个月。在研究开始和结束时采集空腹血样，用于分析脂质标志物和黄酮醇。
与安慰剂相比，食用SBB显著提高了黄酮醇槲皮素和异鼠李素的血浆浓度[治疗差异分别为3.0纳克/毫升（P = 0.03）和3.9纳克/毫升（P < 0.01）]。山奈酚浓度的增加不显著[治疗差异为0.7纳克/毫升（P = 0.08）]。SBB对血清总胆固醇、高密度脂蛋白、低密度脂蛋白胆固醇或血清三酰甘油浓度没有影响。参与者的黄酮醇浓度变化与CRP浓度之间没有相关性。
食用SBB显著提高了空腹血浆中槲皮素和异鼠李素的浓度，表明它是黄酮醇的良好膳食来源。然而，这并未转化为对饮食健康的正常血脂健康成年人循环脂质标志物浓度的影响。
