分析溶质载体（SLC）家族39个基因在胃癌中的预后价值。
Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer.
作者信息
Ding Bisha, Lou Weiyang, Xu Liang, Li Ruohan, Fan Weimin
机构信息
Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation Hangzhou 310003, Zhejiang Province, China.
Department of Emergency Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 710004, Shaanxi Province, China.
出版信息
Am J Transl Res. 2019 Jan 15;11(1):486-498. eCollection 2019.
BACKGROUND
Gastric cancer (GC) is one of the most common diagnosed cancer with poor prognosis. Solute carrier (SLC) family 39 genes encode membrane transport proteins, which control the influx of zinc and may play important roles in human disease including cancer. However, the prognostic value of individual SLC family 39 gene in gastric cancer patients remain unclear.
METHODS
Genetic alteration frequency and mRNA expression level of SLC family 39 genes in GC were first assessed by using many online databases including cBioportal for Cancer Genomics, Oncomine, UCSC Xena browser and Ualcan database. The prognostic value of individual SLC family 39 gene in GC patients were further investigated via Kaplan-Meier plotter.
RESULTS
The analytic results of genetic alteration frequency showed that mRNA deregulation was one of the most important single factors for alteration in different kinds of gastric cancer. Compared with normal gastric tissues, 14 SLC family 39 genes were all significantly upregulated in GC tissue in Ualcan database, and mRNA expression were also higher in Oncomine database. The survival analysis indicated that most members of SLC family 39 genes were closely related with prognosis of GC patients, were significantly associated with favorable overall survival (OS), the rest of SLC family 39 genes were importantly correlated with unfavorable OS except .
CONCLUSION
Our analysis identified that 14 SLC family 39 genes are potential prognostic biomarkers of GC patients, and may offer effective and new strategies for GC therapy.
背景
胃癌（GC）是最常被诊断出的癌症之一，预后较差。溶质载体（SLC）家族39基因编码膜转运蛋白，其控制锌的流入，可能在包括癌症在内的人类疾病中发挥重要作用。然而，单个SLC家族39基因在胃癌患者中的预后价值仍不清楚。
方法
首先通过使用许多在线数据库，包括癌症基因组学的cBioportal、Oncomine、UCSC Xena浏览器和Ualcan数据库，评估GC中SLC家族39基因的基因改变频率和mRNA表达水平。通过Kaplan-Meier绘图仪进一步研究单个SLC家族39基因在GC患者中的预后价值。
结果
基因改变频率的分析结果表明，mRNA失调是不同类型胃癌改变的最重要单一因素之一。与正常胃组织相比，Ualcan数据库中14个SLC家族39基因在GC组织中均显著上调，Oncomine数据库中的mRNA表达也更高。生存分析表明，SLC家族39基因的大多数成员与GC患者的预后密切相关，与良好的总生存期（OS）显著相关，除了 之外，SLC家族39基因的其余成员与不良OS密切相关。
结论
我们的分析确定了14个SLC家族39基因是GC患者潜在的预后生物标志物，并可能为GC治疗提供有效和新的策略。
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