优化肺部立体定向体部放射治疗的固定、边界和成像。
Optimizing immobilization, margins, and imaging for lung stereotactic body radiation therapy.
作者信息
Molitoris Jason K, Diwanji Tejan, Snider James W, Mossahebi Sina, Samanta Santanu, Onyeuku Nasarachi, Mohindra Pranshu, Choi J Isabelle, Simone Charles B
机构信息
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD, USA.
出版信息
Transl Lung Cancer Res. 2019 Feb;8(1):24-31. doi: 10.21037/tlcr.2018.09.25.
Abstract
The simultaneous advancement of technologies for the delivery of precisely targeted radiation therapy and the paradigm shift to substantial hypofractionation have led to significant improvements in the treatment of early stage non-small cell lung cancer (ES-NSCLC). Stereotactic body radiation therapy (SBRT) has become a well-established option for the treatment of ES-NSCLC and is now becoming widely available within the radiation oncology community. Implementation of this technique, however, requires highly accurate target delineation, thorough evaluation of tumor motion, and improved on-board imaging at the time of treatment for patient alignment, each of which is critical for successful tumor control and mitigation of risks to normal tissues. In this article, we review updates and issues related to immobilization and image guidance for SBRT in the treatment of ES-NSCLC.
摘要
精确靶向放射治疗技术的同步发展以及向大分割放疗模式的转变，已使早期非小细胞肺癌（ES-NSCLC）的治疗取得显著进展。立体定向体部放射治疗（SBRT）已成为治疗ES-NSCLC的成熟选择，目前在放射肿瘤学界正广泛应用。然而，实施该技术需要高度精确的靶区勾画、对肿瘤运动的全面评估以及治疗时用于患者体位校准的改进型机载成像，其中每一项对于成功控制肿瘤和降低对正常组织的风险都至关重要。在本文中，我们回顾了与ES-NSCLC治疗中SBRT的固定和图像引导相关的进展及问题。
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