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[男性下尿路症状的新型微创治疗选择]

[Novel minimally invasive treatment options for male lower urinary tract symptom].

作者信息

Magistro G, Stief C G, Gratzke C

机构信息

Urologische Klinik und Poliklinik der Universität München, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland.

Klinik für Urologie, Universitätsklinikum Freiburg, Freiburg, Deutschland.

出版信息

Urologe A. 2019 Mar;58(3):254-262. doi: 10.1007/s00120-019-0876-7.

DOI:10.1007/s00120-019-0876-7
PMID:30790004
Abstract

Novel minimally invasive treatment options strive for innovative approaches that are equally efficient to standard procedures with a superior safety profile. A true minimally invasive technique can be performed in an ambulatory setting under local anaesthesia and no need for postinterventional catheterization so that quick and problem-free return to everyday life is possible. Sexual dysfunction is a great concern of sexually active patients facing surgery. The novel techniques clearly demonstrate that relief of bothersome lower urinary tract symptoms (LUTS) is possible without compromising erectile and ejaculatory function. Urolift® is an attractive treatment option for carefully selected patients without a middle lobe who have special interest in the rapid and smooth return to daily activity and the complete preservation of sexual function. Rezũm® and AquaBeam® are promising novel techniques that can be also performed in the presence of certain prostatic features like a middle lobe. iTIND® is still in its infancy of clinical evaluation and therefore, its true value still needs to be determined. According to current data the role of intraprostatic injectables for the treatment of male LUTS is still unclear.

摘要

新型微创治疗方案致力于采用创新方法,这些方法在安全性方面优于标准程序,同时效率相当。真正的微创技术可在门诊局部麻醉下进行,无需介入后导管插入术,从而能够快速且顺利地恢复日常生活。性功能障碍是接受手术的性活跃患者极为关注的问题。新技术清楚地表明,在不损害勃起和射精功能的情况下,缓解令人烦恼的下尿路症状(LUTS)是可能的。对于精心挑选的没有中叶且特别希望快速顺利恢复日常活动并完全保留性功能的患者,Urolift®是一种有吸引力的治疗选择。Rezũm®和AquaBeam®是有前景的新技术,在存在某些前列腺特征(如中叶)的情况下也可进行。iTIND®仍处于临床评估的初期阶段,因此其真正价值仍有待确定。根据目前的数据,前列腺内注射剂在治疗男性LUTS中的作用仍不明确。

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[Treatment of benign prostatic hyperplasia in geriatric patients-use and limitations of existing guidelines].老年患者良性前列腺增生的治疗——现有指南的应用与局限性
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本文引用的文献

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Randomized Controlled Trial of Aquablation versus Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia: One-year Outcomes.良性前列腺增生症中 Aquablation 与经尿道前列腺切除术的随机对照试验:一年结果
Urology. 2019 Mar;125:169-173. doi: 10.1016/j.urology.2018.12.002. Epub 2018 Dec 12.
2
Do patients have to choose between ejaculation and miction? A systematic review about ejaculation preservation technics for benign prostatic obstruction surgical treatment.患者是否必须在射精和排尿之间做出选择?良性前列腺梗阻手术治疗中保留射精技术的系统评价。
World J Urol. 2019 Feb;37(2):299-308. doi: 10.1007/s00345-018-2368-6. Epub 2018 Jul 2.
3
Fexapotide triflutate: results of long-term safety and efficacy trials of a novel injectable therapy for symptomatic prostate enlargement.
非那雄胺三氟酸盐:一种新型注射治疗前列腺增生症的长期安全性和疗效试验结果。
World J Urol. 2018 May;36(5):801-809. doi: 10.1007/s00345-018-2185-y. Epub 2018 Jan 29.
4
WATER: A Double-Blind, Randomized, Controlled Trial of Aquablation vs Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia.水:良性前列腺增生症经尿道前列腺电切术与 Aquablation 治疗的双盲、随机、对照试验。
J Urol. 2018 May;199(5):1252-1261. doi: 10.1016/j.juro.2017.12.065. Epub 2018 Jan 31.
5
3-Year follow-up of temporary implantable nitinol device implantation for the treatment of benign prostatic obstruction.良性前列腺梗阻治疗中临时可植入镍钛诺装置的 3 年随访。
BJU Int. 2018 Jul;122(1):106-112. doi: 10.1111/bju.14141. Epub 2018 Feb 14.
6
Three-Year Outcomes of the Prospective, Randomized Controlled Rezūm System Study: Convective Radiofrequency Thermal Therapy for Treatment of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia.前瞻性随机对照Rezūm系统研究的三年结果:对流射频热疗法治疗良性前列腺增生引起的下尿路症状
Urology. 2018 Jan;111:1-9. doi: 10.1016/j.urology.2017.10.023. Epub 2017 Nov 6.
7
Emerging Minimally Invasive Treatment Options for Male Lower Urinary Tract Symptoms.男性下尿路症状的新兴微创治疗选择。
Eur Urol. 2017 Dec;72(6):986-997. doi: 10.1016/j.eururo.2017.07.005. Epub 2017 Jul 19.
8
State of the art: Advanced techniques for prostatic urethral lift for the relief of prostate obstruction under local anesthesia.最新技术:局部麻醉下前列腺尿道悬吊术治疗前列腺梗阻的先进技术。
Can J Urol. 2017 Jun;24(3):8859-8864.
9
Five year results of the prospective randomized controlled prostatic urethral L.I.F.T. study.前列腺尿道L.I.F.T.前瞻性随机对照研究的五年结果。
Can J Urol. 2017 Jun;24(3):8802-8813.
10
Holmium Laser Enucleation of the Prostate After Prostatic Urethral Lift Surgery: Feasibility and Technical Considerations from a Multi-Institutional Case Series.前列腺尿道悬吊术后钬激光前列腺剜除术:来自多机构病例系列的可行性及技术考量
J Endourol. 2017 Aug;31(8):774-779. doi: 10.1089/end.2017.0224. Epub 2017 Jul 5.