Ginsburg I
Department of Oral Biology, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem, Israel.
Microbiol Sci. 1988 May;5(5):137-42.
Degradation of cell wall components of certain microbial species following phagocytosis by neutrophils and macrophages might involve the activation, by leucocyte cationic proteins, of the bacterial autolytic wall enzymes, leading to bacteriolysis. Lysozyme (a distinct cationic agent), which is the main muramidase present in leucocytes and in body fluids, might function not only as an enzyme but also as a potent activator of autolysis. Sulphated polyelectrolytes, proteolytic enzymes and oxygen radicals, which are released in inflammatory sites, might inactivate the autolytic wall enzymes, leading to the accumulation of peptidoglycan-polysaccharide complexes within macrophages. Activated macrophages are instrumental in initiating chronic inflammatory reactions. Undegraded microbial cell wall components also function as immunomodulators and as enhancers of non-specific resistance to infections and to malignancy.
中性粒细胞和巨噬细胞吞噬某些微生物物种后，其细胞壁成分的降解可能涉及白细胞阳离子蛋白对细菌自溶壁酶的激活，从而导致细菌溶解。溶菌酶（一种独特的阳离子剂）是白细胞和体液中存在的主要溶菌酶，它可能不仅作为一种酶发挥作用，还作为自溶的有效激活剂。在炎症部位释放的硫酸化聚电解质、蛋白水解酶和氧自由基可能会使自溶壁酶失活，导致肽聚糖 - 多糖复合物在巨噬细胞内积累。活化的巨噬细胞在引发慢性炎症反应中起作用。未降解的微生物细胞壁成分也作为免疫调节剂以及对感染和恶性肿瘤的非特异性抵抗力增强剂发挥作用。
