Sun Wei, Singh Amit K
Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208 USA.
NPJ Vaccines. 2019 Feb 18;4:11. doi: 10.1038/s41541-019-0105-9. eCollection 2019.
Three great plague pandemics, resulting in nearly 200 million deaths in human history and usage as a biowarfare agent, have made as one of the most virulent human pathogens. In late 2017, a large plague outbreak raged in Madagascar attracted extensive attention and caused regional panics. The evolution of local outbreaks into a pandemic is a concern of the Centers for Disease Control and Prevention (CDC) in plague endemic regions. Until now, no licensed plague vaccine is available. Prophylactic vaccination counteracting this disease is certainly a primary choice for its long-term prevention. In this review, we summarize the latest advances in research and development of plague vaccines.
三次重大鼠疫大流行在人类历史上导致了近2亿人死亡，并被用作生物战剂，使其成为最具毒性的人类病原体之一。2017年末，马达加斯加爆发的大规模鼠疫疫情引起了广泛关注并导致地区恐慌。在鼠疫流行地区，局部疫情演变为大流行是疾病控制与预防中心（CDC）关注的问题。到目前为止，尚无获得许可的鼠疫疫苗。通过预防性接种疫苗来对抗这种疾病无疑是其长期预防的首要选择。在本综述中，我们总结了鼠疫疫苗研发的最新进展。
