Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
PLoS One. 2019 Feb 22;14(2):e0212736. doi: 10.1371/journal.pone.0212736. eCollection 2019.
Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.
水杨酸（SA）是一种有效的诱导剂，可以增加微孢拟盘多毛孢中产紫杉醇的产量。在 300μM 的浓度下添加 SA，可产生 625.47μg/L 的紫杉醇，比对照组高出 45 倍。SA 在真菌紫杉醇生物合成途径中的作用的研究表明，SA 增强了微孢拟盘多毛孢菌丝的活性氧和不饱和脂肪酸的脂质过氧化。这个氧化过程通过触发香叶基香叶基焦磷酸合酶基因的表达来刺激异戊二烯生物合成途径，从而提高微孢拟盘多毛孢中紫杉醇的生物合成。
