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致心律失常物质对高剂量维生素D2致大鼠钙化模型心电图的影响

The influence of arrhythmogenic substances on the E.C.G. of rats calcified by high doses of vitamin D2.

作者信息

Baraka Y M, Bekemeier H

出版信息

Arch Toxicol Suppl. 1978(1):365-8. doi: 10.1007/978-3-642-66896-8_80.

DOI:10.1007/978-3-642-66896-8_80
PMID:307947
Abstract

Calcification of the aorta and the coronary vessels as well as metastatic calcification of the heart muscle in the rat was produced by daily oral administration of 300,000 i.u. vitamin D2/kg for 6 consecutive days. E.C.G. tracings showed different pathological conditions. The response of the cardiovascular system to certain arrhythmogenic substances, e.g. aconitine and CaCl2 was generally reduced in comparison to non-treated rats.

摘要

通过连续6天每天口服300,000国际单位维生素D2/千克,在大鼠中诱发主动脉和冠状动脉钙化以及心肌转移性钙化。心电图记录显示出不同的病理状况。与未处理的大鼠相比,心血管系统对某些致心律失常物质(如乌头碱和氯化钙)的反应普遍降低。

相似文献

1
The influence of arrhythmogenic substances on the E.C.G. of rats calcified by high doses of vitamin D2.致心律失常物质对高剂量维生素D2致大鼠钙化模型心电图的影响
Arch Toxicol Suppl. 1978(1):365-8. doi: 10.1007/978-3-642-66896-8_80.
2
[Interrelations between quinidine distribution in the brain and myocardial arrhythmogenic readiness to aconitine and calcium chloride in postnatal ontogeny].[出生后个体发育过程中奎尼丁在脑内的分布与心肌对乌头碱和氯化钙致心律失常易感性之间的相互关系]
Farmakol Toksikol. 1985 Mar-Apr;48(2):59-63.
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[Antiarrhythmic effects of prostaglandin E1, A1 and F2beta against CaCl2- and aconitin-arrhythmias in the rat].[前列腺素E1、A1和F2β对大鼠氯化钙和乌头碱所致心律失常的抗心律失常作用]
Acta Biol Med Ger. 1974;33(2):245-8.
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[Aconitine-induced arrhythmia in animals with various learning speeds].
Fiziol Zh SSSR Im I M Sechenova. 1989 Feb;75(2):260-2.
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Do endogenous lipoproteins modulate the sensibility of animals against arrhythmogenic drugs?内源性脂蛋白是否会调节动物对致心律失常药物的敏感性?
Prostaglandins Leukot Med. 1987 Jul;28(2):215-20. doi: 10.1016/0262-1746(87)90165-x.
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Effects of lithium on time to onset of aconitine-induced initial arrhythmia and ventricular tachycardia.
Arch Int Pharmacodyn Ther. 1979 Aug;240(2):249-56.
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Putrescine reverses aconitine-induced arrhythmia in rats.腐胺可逆转乌头碱诱导的大鼠心律失常。
J Pharm Pharmacol. 1989 Sep;41(9):651-3. doi: 10.1111/j.2042-7158.1989.tb06552.x.
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Involvement of Central adrenergic mechanisms in the induction of cardiac arrhythmias by aconitine nitrate administered intraventricularly.中枢肾上腺素能机制参与硝酸乌头碱脑室内给药诱发心律失常的过程。
Indian J Physiol Pharmacol. 1975 Jan-Mar;19(1):1-10.
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Prilocaine effect on aconitine-induced arrhythmias.丙胺卡因对乌头碱诱发心律失常的影响。
Acta Physiol Lat Am. 1978;28(4-5):201-7.
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Hemodynamic and arrhythmogenic effects of aconitine applied to the left atria of anesthetized cats. Effects of amiodarone and atropine.乌头碱对麻醉猫左心房的血流动力学及致心律失常作用。胺碘酮和阿托品的作用。
J Cardiovasc Pharmacol. 1981 Jan-Feb;3(1):87-100. doi: 10.1097/00005344-198101000-00008.

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