快照：溶瘤病毒的癌症免疫疗法。
SnapShot: Cancer Immunotherapy with Oncolytic Viruses.
机构信息
Departments of Pathology, Biology, and Microbiology & Immunolgy, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Departments of Medicine & Biochemistry and Microbiology & Immunology, University of Ottawa, ON, Canada; Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
出版信息
Cell. 2019 Feb 21;176(5):1240-1240.e1. doi: 10.1016/j.cell.2019.01.051.
Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.
溶瘤病毒（OVs）优先感染和杀死癌细胞，而不伤害正常细胞。OVs 可以逆转与癌症相关的免疫抑制，并引发具有临床意义的抗肿瘤免疫反应。OVs 及其引起的免疫事件可以在原发和转移部位发挥作用。因此，OVs 可单独用于癌症基因治疗和免疫治疗，也可与其他干预措施（包括免疫检查点阻断）联合使用。
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