Health and Social Research Centre, University of Castilla-La Mancha, Cuenca, Spain.
Faculty of Nursing, University of Castilla-La Mancha, Cuenca, Spain.
Scand J Med Sci Sports. 2018 Jul;28(7):1801-1807. doi: 10.1111/sms.13077. Epub 2018 Mar 12.
The aim of this study was to analyze the mediation role of cardiorespiratory fitness and waist circumference in the association between muscular strength and cardiometabolic risk. A cross-sectional study involved first-year college students (n = 370) from a Spanish public university was performed. We measured weight, height, waist circumference, blood pressure, biochemical variables, maximum handgrip strength assessment, and cardiorespiratory fitness. We calculated handgrip dynamometry/weight and a previously validated cardiometabolic risk index. Analysis of covariance models was conducted to test differences in cardiometabolic risk values across muscular strength, cardiorespiratory fitness, and waist circumference categories, controlling for confounders. Hayes' PROCESS macro was used for the multiple mediation analysis. The relationship between muscular strength and cardiometabolic risk did not remain significant (c' = 1.76 [1.4]; P > .05) in a multiple serial bootstrapped mediation model including cardiorespiratory fitness and waist circumference as mediators when controlling for age and sex. According to the indirect effect, the significant paths in the model mediating this relationship between muscular strength and cardiometabolic risk index were as follows: muscular strength → waist circumference → cardiometabolic risk index (-4.899; 95% CI: -6.690; -3.450) and muscular strength → cardiorespiratory fitness → waist circumference → cardiometabolic risk index (-0.720; 95% CI: -1.316; -0.360). Both cardiorespiratory fitness and waist circumference mediate the association between muscular strength and cardiometabolic risk in young adults. Thus, our results place cardiorespiratory fitness and waist circumference as the main targets of physical activity programmes aimed at preventing cardiometabolic diseases.
本研究旨在分析心肺适能和腰围在肌肉力量与心血管代谢风险之间的关联中的中介作用。一项横断面研究涉及西班牙一所公立大学的一年级大学生（n=370）。我们测量了体重、身高、腰围、血压、生化变量、最大握力评估和心肺适能。我们计算了握力动力/体重和之前验证过的心血管代谢风险指数。协方差模型分析用于测试肌肉力量、心肺适能和腰围类别之间心血管代谢风险值的差异，同时控制混杂因素。使用 Hayes' PROCESS 宏进行多重中介分析。在包含心肺适能和腰围作为中介的多重串行 bootstrap 中介模型中，当控制年龄和性别时，肌肉力量与心血管代谢风险之间的关系不再具有统计学意义（c'=1.76 [1.4]；P>.05）。根据间接效应，模型中介肌肉力量与心血管代谢风险指数之间关系的显著路径如下：肌肉力量→腰围→心血管代谢风险指数（-4.899；95%CI：-6.690；-3.450）和肌肉力量→心肺适能→腰围→心血管代谢风险指数（-0.720；95%CI：-1.316；-0.360）。心肺适能和腰围均介导了年轻人肌肉力量与心血管代谢风险之间的关联。因此，我们的结果将心肺适能和腰围作为预防心血管代谢疾病的身体活动计划的主要目标。
