Systemic Autoimmune Diseases Unit, Department of Internal Medicine, "Virgen de las Nieves" University Hospital, Granada, Spain.
Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.
Eur J Clin Invest. 2018 Mar;48(3). doi: 10.1111/eci.12885. Epub 2018 Feb 2.
The aim of this study was twofold: (i) to examine the association of cardiorespiratory fitness with arterial stiffness in women with systemic lupus erythematosus; (ii) to assess the potential interaction of cardiorespiratory fitness with age on arterial stiffness in this population.
A total of 49 women with systemic lupus erythematosus (mean age 41.3 [standard deviation 13.8] years) and clinical stability during the previous 6 months were included in the study. Arterial stiffness was assessed through pulse wave velocity (Mobil-O-Graph® 24 hours pulse wave velocity monitor). Cardiorespiratory fitness was estimated with the Siconolfi step test and the 6-minute walk test.
Cardiorespiratory fitness was inversely associated with pulse wave velocity in crude analyses (P < .05), although this relationship was attenuated when age and other cardiovascular risk factors were controlled. There was a cardiorespiratory fitness × age interaction effect on pulse wave velocity, regardless of the test used to estimate cardiorespiratory fitness (P < .001 for the Siconolfi step test; P = .005 for the 6-minute walk test), indicating that higher cardiorespiratory fitness was associated with a lower increase in pulse wave velocity per each year increase in age.
The results of this study suggest that cardiorespiratory fitness might attenuate the age-related arterial stiffening in women with systemic lupus erythematosus and might thus contribute to the primary prevention of cardiovascular disease in this population. As the cross-sectional design precludes establishing causal relationships, future clinical trials should confirm or contrast these findings.
本研究旨在：（i）检测系统性红斑狼疮女性中心肺适能与动脉僵硬度的相关性；（ii）评估该人群中心肺适能与年龄对动脉僵硬度的潜在交互作用。
共纳入 49 名系统性红斑狼疮女性（平均年龄 41.3[13.8]岁），且在过去 6 个月内病情稳定。通过脉搏波速度（Mobil-O-Graph®24 小时脉搏波速度监测仪）评估动脉僵硬度。心肺适能采用西科诺尔夫台阶试验和 6 分钟步行试验进行评估。
在未经校正的分析中，心肺适能与脉搏波速度呈负相关（P<0.05），但当控制年龄和其他心血管危险因素后，这种相关性减弱。无论使用哪种方法来评估心肺适能，都存在心肺适能与年龄的交互作用（P<0.001 用于西科诺尔夫台阶试验；P=0.005 用于 6 分钟步行试验），这表明心肺适能越高，每增加 1 岁，脉搏波速度的增加幅度越低。
本研究结果表明，心肺适能可能会减弱系统性红斑狼疮女性的年龄相关动脉僵硬度，从而有助于该人群心血管疾病的一级预防。由于横断面设计无法确定因果关系，未来的临床试验应证实或反驳这些发现。
