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基于其抗氧化特性，氧化铈纳米颗粒对 UVA 辐射诱导的人皮肤成纤维细胞衰老的光保护作用。

Photoprotection of Cerium Oxide Nanoparticles against UVA radiation-induced Senescence of Human Skin Fibroblasts due to their Antioxidant Properties.

机构信息

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.

Department of Dermatology, the Affiliated Huai'an Hospital of Xuzhou Medical University, the Second People's Hospital of Huai'an, Huai'an, 223002, China.

出版信息

Sci Rep. 2019 Feb 22;9(1):2595. doi: 10.1038/s41598-019-39486-7.

DOI:10.1038/s41598-019-39486-7
PMID:30796322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6385175/
Abstract

Ultraviolet (UV) irradiation, particularly ultraviolet A (UVA), stimulates reactive oxygen species (ROS) production in the epidermis and dermis, which plays a major part in the photoageing of human skin. Several studies have demonstrated that cerium oxide nanoparticles (CeO NP) can exhibit an antioxidant effect and free radical scavenging activity. However, the protective role of CeO NP in skin photoageing and the underlying mechanisms are unclear. In this study, we investigated the effects of CeO NP on UVA-irradiated human skin fibroblasts (HSFs) and explored the potential signalling pathway. CeO NP had no apparent cytotoxicity, and could reduce the production of proinflammatory cytokines, intracellular ROS, senescence-associated β-galactosidase activity, and downregulate phosphorylation of c-Jun N-terminal kinases (JNKs) after exposure to UVA radiation. Based on our findings, CeO NPs have great potential against UVA radiation-induced photoageing in HSFs via regulating the JNK signal-transduction pathway to inhibit oxidative stress and DNA damage.

摘要

紫外线（UV）辐射，特别是紫外线 A（UVA），会刺激表皮和真皮产生活性氧（ROS），这在人类皮肤的光老化中起着重要作用。多项研究表明，氧化铈纳米粒子（CeO NP）具有抗氧化作用和自由基清除活性。然而，CeO NP 在皮肤光老化中的保护作用及其潜在机制尚不清楚。在本研究中，我们研究了 CeO NP 对 UVA 辐射的人皮肤成纤维细胞（HSFs）的影响，并探讨了潜在的信号通路。CeO NP 无明显细胞毒性，可减少促炎细胞因子的产生、细胞内 ROS、衰老相关的β-半乳糖苷酶活性，并下调 UVA 辐射后 c-Jun N 末端激酶（JNK）的磷酸化。基于我们的发现，CeO NPs 通过调节 JNK 信号转导通路抑制氧化应激和 DNA 损伤，具有对抗 HSFs 中 UVA 辐射诱导的光老化的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/a81dd2d14966/41598_2019_39486_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/0ec650f10cd0/41598_2019_39486_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/bebc381ec7e2/41598_2019_39486_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/84da3d837db7/41598_2019_39486_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/66bcb5d5ab94/41598_2019_39486_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/a81dd2d14966/41598_2019_39486_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/0ec650f10cd0/41598_2019_39486_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/a9d98f506a9e/41598_2019_39486_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/bebc381ec7e2/41598_2019_39486_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/84da3d837db7/41598_2019_39486_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/66bcb5d5ab94/41598_2019_39486_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bde6/6385175/a81dd2d14966/41598_2019_39486_Fig6_HTML.jpg

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2
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Nanomedicine (Lond). 2018 Nov;13(22):2821-2833. doi: 10.2217/nnm-2018-0316. Epub 2018 Oct 18.
3
Biological Stimulus-Driven Assembly/Disassembly of Functional Nanoparticles for Targeted Delivery, Controlled Activation, and Bioelimination.
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Int J Nanomedicine. 2024 Jun 25;19:6463-6483. doi: 10.2147/IJN.S459607. eCollection 2024.
4
Reactive oxygen species-scavenging nanomaterials for the prevention and treatment of age-related diseases.用于预防和治疗与年龄相关疾病的活性氧清除纳米材料。
J Nanobiotechnology. 2024 May 15;22(1):252. doi: 10.1186/s12951-024-02501-9.
5
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