人类自然体感感知后场电位的皮层脑电图变化。
Electrocorticographic changes in field potentials following natural somatosensory percepts in humans.
作者信息
Kramer Daniel R, Barbaro Michael F, Lee Morgan, Peng Terrance, Nune George, Liu Charles Y, Kellis Spencer, Lee Brian
机构信息
Department of Neurosurgery, University of Southern California, 1200 N. State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Neurorestoration Center, University of Southern California, Los Angeles, CA, USA.
出版信息
Exp Brain Res. 2019 May;237(5):1155-1167. doi: 10.1007/s00221-019-05495-1. Epub 2019 Feb 22.
OBJECTIVE
Restoration of somatosensory deficits in humans requires a clear understanding of the neural representations of percepts. To characterize the cortical response to naturalistic somatosensation, we examined field potentials in the primary somatosensory cortex of humans.
METHODS
Four patients with intractable epilepsy were implanted with subdural electrocorticography (ECoG) electrodes over the hand area of S1. Three types of stimuli were applied, soft-repetitive touch, light touch, and deep touch. Power in the alpha (8-15 Hz), beta (15-30 Hz), low-gamma (30-50 Hz), and high-gamma (50-125 Hz) frequency bands were evaluated for significance.
RESULTS
Seventy-seven percent of electrodes over the hand area of somatosensory cortex exhibited changes in these bands. High-gamma band power increased for all stimuli, with concurrent alpha and beta band power decreases. Earlier activity was seen in these bands in deep touch and light touch compared to soft touch.
CONCLUSIONS
These findings are consistent with prior literature and suggest a widespread response to focal touch, and a different encoding of deeper pressure touch than soft touch.
目的
恢复人类的体感缺陷需要清楚了解感知的神经表征。为了描述对自然体感的皮层反应，我们检测了人类初级体感皮层的场电位。
方法
4例顽固性癫痫患者在S1手部区域植入硬膜下皮质脑电图（ECoG）电极。应用了三种类型的刺激，即轻柔重复触摸、轻触和深触。评估了α（8 - 15赫兹）、β（15 - 30赫兹）、低γ（30 - 50赫兹）和高γ（50 - 125赫兹）频段的功率是否具有显著性。
结果
体感皮层手部区域77%的电极在这些频段出现变化。所有刺激下高γ频段功率均增加，同时α和β频段功率降低。与轻柔触摸相比，深触和轻触在这些频段的活动更早出现。
结论
这些发现与先前文献一致，提示对局灶性触摸有广泛反应，且对较深压力触摸的编码与轻柔触摸不同。
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