School of Life and Technology, Xinxiang Medical University, Xinxiang, Henan, 453003, PR China.
Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou University, Guangdong, 515063, PR China.
Anal Chim Acta. 2019 May 16;1056:108-116. doi: 10.1016/j.aca.2018.12.045. Epub 2019 Jan 2.
The excellent anticancer effect of combined differential cancer therapies has been observed in the last few decades. Efficient theragnostic nanoparticles (NPs) for malignancy treatment have received considerable research attention and widely investigated today. This study presents our results on the development of aptamer-functionalized FeO@carbon@doxorubicin NPs (Apt-FeO@C@DOX) and their application in the synergetic chemo-photothermal therapy (PTT) of cancer. The Apt-FeO@C@DOX NPs displayed high photothermal conversion efficiency and extensive pH/heat-induced drug release. In vitro (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) bromide experiments indicated that the combined chemo-PTT is much more toxic toward lung adenocarcinoma cells (A549) than PTT or chemotherapy alone. In addition, the Apt-FeO@C@DOX NPs demonstrated decreasing contrast enhancement of magnetic resonance (MR) signals, which means they may be potentially applied as a contrast agent and serve as a critical component of T-weighted MR imaging of tumor tissues. Taking the results together, the Apt-FeO@C@DOX NPs show great potential for cancer therapy.
在过去几十年中，联合差异化癌症疗法的优异抗癌效果已经得到了观察。高效的治疗恶性肿瘤的治疗诊断纳米粒子（NPs）引起了相当多的研究关注，并得到了广泛的研究。本研究介绍了我们在开发适体功能化 FeO@carbon@doxorubicin NPs（Apt-FeO@C@DOX）及其在癌症协同化学-光热治疗（PTT）中的应用方面的结果。Apt-FeO@C@DOX NPs 表现出高的光热转换效率和广泛的 pH/热诱导药物释放。体外（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑）溴化物实验表明，联合化学-PTT 对肺腺癌细胞（A549）的毒性比 PTT 或单独化疗要强得多。此外，Apt-FeO@C@DOX NPs 表现出磁共振（MR）信号对比度降低，这意味着它们可能潜在地用作造影剂，并作为肿瘤组织 T 加权 MR 成像的关键组成部分。综合这些结果，Apt-FeO@C@DOX NPs 显示出在癌症治疗方面的巨大潜力。
