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结核分枝杆菌记忆性免疫T淋巴细胞对非结核分枝杆菌感染的交叉保护作用。

Crossprotection against nontuberculous mycobacterial infections by Mycobacterium tuberculosis memory immune T lymphocytes.

作者信息

Orme I M, Collins F M

出版信息

J Exp Med. 1986 Jan 1;163(1):203-8. doi: 10.1084/jem.163.1.203.

Abstract

Adoptive immunization of T cell-deficient recipient mice with M. tuberculosis-specific memory immune T lymphocytes conferred upon these animals the ability to express significantly enhanced resistance both to the homologous infection, and to three strains of nontuberculous mycobacteria. These results support the hypothesis, therefore, that antigenic determinants possessed by the four mycobacterial strains that are relevant to the generation of protective cellular immunity are identical or closely crossreactive.

摘要

用结核分枝杆菌特异性记忆免疫T淋巴细胞对T细胞缺陷的受体小鼠进行过继免疫,使这些动物对同源感染以及三种非结核分枝杆菌菌株都表现出显著增强的抵抗力。因此,这些结果支持了这样一种假说,即与保护性细胞免疫产生相关的四种分枝杆菌菌株所具有的抗原决定簇是相同的或密切交叉反应的。

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