Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box: 15875-4413, Iran.
Department of Polymer and Color Engineering, Amirkabir University of Technology, P.O. Box: 15875-4413, Iran.
Med Hypotheses. 2019 Mar;124:91-94. doi: 10.1016/j.mehy.2019.02.023. Epub 2019 Feb 4.
Recently, magnetic Hyperthermia is one of the promising methods for cancer treatments. In this method by applying magnetic fields and generating heat, cancerous tissues are eliminated. The degree and pattern of generated heat in cancerous and adjacent non-cancerous tissues plays an important role on the outcome of the treatment. it is mainly affected by diffusion and distribution pattern of magnetic nanoparticles within the cancerous and non-cancerous tissues. Study the diffusion and distribution patterns of magnetic nanoparticle in vivo is difficult and costly in many cases and in some cases evaluating the amount of generated heat at cancer site is almost impossible. In vitro models for cancer tissues are alternatives for in vivo models. However, usual in vitro models could not resembling all the characteristics of a cancer tumor. In this hypothesis we propose that using 3D printers can provide a platform to fabricate a personalized in vitro cancer model which could simulate the most important features of the cancerous tissues (including shape and vascular network) and can be used to study magnetic hyperthermia in a simulated media of compatible to in vivo conditions.
最近，磁热疗是癌症治疗中很有前途的方法之一。在这种方法中，通过施加磁场并产生热量，可以消除癌组织。在癌组织和相邻的非癌组织中产生的热量的程度和模式对治疗效果起着重要作用。它主要受到磁性纳米粒子在癌组织和非癌组织中的扩散和分布模式的影响。在许多情况下，研究体内磁性纳米粒子的扩散和分布模式既困难又昂贵，在某些情况下，评估癌灶处产生的热量几乎是不可能的。癌症组织的体外模型是体内模型的替代方法。然而，通常的体外模型不能模拟出癌症肿瘤的所有特征。在本假说中，我们提出使用 3D 打印机可以提供一个制造个性化体外癌症模型的平台，该模型可以模拟癌组织的最重要特征（包括形状和血管网络），并可用于在与体内条件相兼容的模拟介质中研究磁热疗。
