Park Heeyoon, Lee Gilho
Department of Urology, Dankook University College of Medicine, Cheonan, Korea.
World J Mens Health. 2019 Sep;37(3):355-363. doi: 10.5534/wjmh.180081. Epub 2019 Feb 12.
Because of the inconsistent symptoms associated with infections, their clinical significances in genitourinary tracts are under debate. Therefore, we evaluated the presence of (UU) and (UP) in urine samples and examined their associations with chronic prostatitis (CP) through a case and control study.
We included 696 nonchlamydial nongonococcal (NCNG) urine samples from men; 350 were categorized into non-inflammatory CP, 88 in inflammatory CP, and 258 in non-CP group. We amplified a region in the urease areas from these samples and determined their biovars using the Sanger method.
Among the NCNG population, the rates of UU, UP, and non-UU/UP were 3.88%, 6.46%, and 89.66%, respectively. The overall infection rates of non-CP, inflammatory CP, and non-inflammatory CP groups were 4.15%, 6.10%, and 3.65% in UU (p=0.612) and 6.85%, 7.22%, and 6.50% in UP (p=0.968), respectively. UU infection increased the risk of white blood cell (WBC) counts (≥5) in urine (p=0.005). In contrast, UP infections did not increase the risks of urethritis. Re-analysis from the 633 men who were excluded from urethritis effects did not reveal the associations between UU infection and the clinical characteristics of CP. Furthermore, the profiles from the National Institutes of Health-Chronic Prostatitis Symptom Index questionnaire and WBC counts in expressed prostatic secretion were similar among the non-CP and the two CP groups in each infection.
We found that UU may induce male urethritis. However, species in urine were not definitively associated with the occurrence of CP.
由于与感染相关的症状不一致，其在泌尿生殖道中的临床意义存在争议。因此，我们通过病例对照研究评估了尿液样本中解脲脲原体（UU）和人型支原体（UP）的存在情况，并研究了它们与慢性前列腺炎（CP）的相关性。
我们纳入了696名男性的非衣原体非淋菌性（NCNG）尿液样本；其中350例被归类为非炎性CP，88例为炎性CP，258例为非CP组。我们从这些样本中扩增了脲原体脲酶区域的一个片段，并使用桑格法确定其生物型。
在NCNG人群中，UU、UP和非UU/UP的比例分别为3.88%、6.46%和89.66%。非CP组、炎性CP组和非炎性CP组的UU总体感染率分别为4.15%、6.10%和3.65%（p = 0.612），UP总体感染率分别为6.85%、7.22%和6.50%（p = 0.968）。UU感染增加了尿液中白细胞（WBC）计数（≥5）的风险（p = 0.005）。相比之下，UP感染并未增加尿道炎的风险。对633名排除尿道炎影响的男性进行的重新分析未发现UU感染与CP临床特征之间的关联。此外，在每种感染情况下，非CP组和两个CP组之间，美国国立卫生研究院慢性前列腺炎症状指数问卷的结果以及前列腺液中的WBC计数相似。
我们发现UU可能诱发男性尿道炎。然而，尿液中的脲原体物种与CP的发生没有明确关联。
